雌性激素可以治疗脑损伤
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纽约（路透社）2006-10-2
最新研究表明，应用黄体酮可以降低脑外伤病人的死亡率和致残率。黄体酮是由卵巢黄体分泌的一种天然孕激素，为维持妊娠所必需。动物研究表明，在损伤之后马上给予黄体酮能够减轻脑水肿，阻止神经死亡和改善功能。首席研究者David W. Wright博士及其同事说，黄体酮优于其它疗法之处在于它能够迅速进入脑内，长时间安全使用，给药方便和廉价。
来自亚特兰大Emory 大学的David W. Wright博士及其同事把100例在脑损伤后11小时内送到急救室的患者作为研究对象。患者被随机分组，分别静脉注射一定剂量的黄体酮或者无作用的安慰剂。黄体酮组损伤后30天死亡率为13%，而对照组则高达30%。这表明黄体酮可降低57%的死亡风险。而且，除了注射部位轻微的炎症反应外，激素和安慰剂的副作用无明显区别。在两组中都未发现严重的副作用。
Wright的研究小组随访到92%的30天内存活的患者。有证据表明黄体酮能够促进中度脑损伤患者的康复，重度脑损伤似乎未从激素治疗中获益。 作者表示，一年期研究结果将在以后报道。这个发现是令人鼓舞的，对这个课题的进一步研究是非常有必要的。
Female hormone may treat brain injuries
Last Updated: 2006-10-02 17:00:42 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Treatment with progesterone, a well-known hormone that prepares the womb for pregnancy, safely reduces the risk of death and disability in people who suffer a traumatic brain injury, new research suggests.
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. Lead researcher Dr. David W. Wright and colleagues note that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration, and low cost.
Wright, from Emory University in Atlanta, and colleagues included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive "placebo".
The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group.
Wright's team was able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to glean no benefit from the hormone.
One-year outcomes will be reported later, the authors note. Still, the findings are encouraging and indicate the need for additional studies to investigate this topic further.
SOURCE: Annals of Emergency Medicine, October 2, 2006, online.
编辑：蓝色幻想
最新研究表明，应用黄体酮可以降低脑外伤病人的死亡率和致残率。黄体酮是由卵巢黄体分泌的一种天然孕激素，为维持妊娠所必需。动物研究表明，在损伤之后马上给予黄体酮能够减轻脑水肿，阻止神经死亡和改善功能。首席研究者David W. Wright博士及其同事说，黄体酮优于其它疗法之处在于它能够迅速进入脑内，长时间安全使用，给药方便和廉价。
来自亚特兰大Emory 大学的David W. Wright博士及其同事把100例在脑损伤后11小时内送到急救室的患者作为研究对象。患者被随机分组，分别静脉注射一定剂量的黄体酮或者无作用的安慰剂。黄体酮组损伤后30天死亡率为13%，而对照组则高达30%。这表明黄体酮可降低57%的死亡风险。而且，除了注射部位轻微的炎症反应外，激素和安慰剂的副作用无明显区别。在两组中都未发现严重的副作用。
Wright的研究小组随访到92%的30天内存活的患者。有证据表明黄体酮能够促进中度脑损伤患者的康复，重度脑损伤似乎未从激素治疗中获益。 作者表示，一年期研究结果将在以后报道。这个发现是令人鼓舞的，对这个课题的进一步研究是非常有必要的。
Female hormone may treat brain injuries
Last Updated: 2006-10-02 17:00:42 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Treatment with progesterone, a well-known hormone that prepares the womb for pregnancy, safely reduces the risk of death and disability in people who suffer a traumatic brain injury, new research suggests.
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. Lead researcher Dr. David W. Wright and colleagues note that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration, and low cost.
Wright, from Emory University in Atlanta, and colleagues included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive "placebo".
The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group.
Wright's team was able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to glean no benefit from the hormone.
One-year outcomes will be reported later, the authors note. Still, the findings are encouraging and indicate the need for additional studies to investigate this topic further.
SOURCE: Annals of Emergency Medicine, October 2, 2006, online.
编辑：蓝色幻想
作者: wingsofdreams 译
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