癌症研究历史经典回顾和热点寻踪（三）
转载请注明来自丁香园
我们一向认为细胞有丝分裂时染色体发生随机分配，然而这不是事实，而且事实表明染色体的非随机分配可能与细胞的分化具有密切关系，因此与癌变关系密切。
1: Cairns J. Mutation selection and the natural history of cancer [J]. Nature.1975,255(5505): 197-200.
2: Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands [J]. J Cell Sci. 2002,115(Pt 11):2381-2388.
3: Merok JR, Lansita JA, Tunstead JR, et.al.Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics [J]. Cancer Res. 2002,62(23):6791-6795
4: Smith GH Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands [J]. Development. 2005, 132(4):681-7.
5: Rambhatla L, Ram-Mohan S, Cheng JJ, et.al..Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells [J].Cancer Res. 2005, 65:3155-61.
6: John Cairns .Cancer and the Immortal Strand Hypothesis.Genetics 2006 174: 1069-1072. doi:10.1534/genetics.104.66886
7: Bell CD. Is mitotic chromatid segregation random? Histol Histopathol. 2005 Oct;20(4):1313-20. Review.
8: Bell CD. Symmetry applied to nuclear microanatomy: a review of gene function and cell differentiation. Histol Histopathol. 2004 Jan;19(1):291-8. Review.
9: Patkin EL. Epigenetic mechanisms for primary differentiation in mammalian embryos. Int Rev Cytol. 2002;216:81-129. Review.
癌症的表型逆转问题一向是癌症研究人员最关心的问题。有那些方式可以逆转癌症表型呢？
外周环境可以逆转部分癌症细胞的表型。
1: Mintz B, Illmensee K.Normal genetically mosaic mice produced from malignant teratocarcinoma cells [J].Proc Natl Acad Sci U S A. 1975, 72(9):3585-9.
2: Illmensee K, Mintz B.Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts [J]. Proc Natl Acad Sci U S A. 1976, 73(2):549-53.
3: Rosen P. On the reversibility of tumor cells.Med Hypotheses. 1981 May;7(5):615-20.
4: Kaiser HE. Biological viewpoints of neoplastic regression.In Vivo. 1994 Jan-Feb;8(1):155-65. Review.
5: Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells.Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):13985-90. Epub 2004 Aug 11. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14305.
6: Pierce GB, Arechaga J, Wells RS. Embryonic control of cancer.
Prog Clin Biol Res. 1986;226:67-77. Review.
7: Barrett JC. A National Institutes of Health Workshop Report. Cellular and molecular mechanisms for suppression and reversion of tumorigenicity. A Chemical Pathology Study Section workshop.Cancer Res. 1987 May 1;47(9):2514-20.
阻断癌基因可以部分逆转癌症表型。
1: Arvanitis C, Felsher DW. Conditional transgenic models define how MYC initiates and maintains tumorigenesis. Semin Cancer Biol. 2006 Aug;16(4):313-7. Epub 2006 Jul 21. Review.
2: Shachaf CM, Felsher DW. Rehabilitation of cancer through oncogene inactivation.Trends Mol Med. 2005 Jul;11(7):316-21. Review.
3: Felsher DW. Reversibility of oncogene-induced cancer.Curr Opin Genet Dev. 2004 Feb;14(1):37-42.
细胞融合可以逆转癌细胞表型：
1: Harris H. The analysis of malignancy by cell fusion: the position in 1988.Cancer Res. 1988 Jun 15;48(12):3302-6.
2: Handmaker SD. Hybridization of eukaryotic cells.Annu Rev Microbiol. 1973;27:189-204. Review.
器官再生能力与癌变概率相反，与逆转癌症概率成正比：
1: Prehn RT. Regeneration versus neoplastic growth. Carcinogenesis. 1997 Aug;18:1439-44.
2: Prehn RT. Immunosurveillance, regeneration and oncogenesis.Prog Exp Tumor Res. 1971;14:1-24. Review.
1: Cairns J. Mutation selection and the natural history of cancer [J]. Nature.1975,255(5505): 197-200.
2: Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands [J]. J Cell Sci. 2002,115(Pt 11):2381-2388.
3: Merok JR, Lansita JA, Tunstead JR, et.al.Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics [J]. Cancer Res. 2002,62(23):6791-6795
4: Smith GH Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands [J]. Development. 2005, 132(4):681-7.
5: Rambhatla L, Ram-Mohan S, Cheng JJ, et.al..Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells [J].Cancer Res. 2005, 65:3155-61.
6: John Cairns .Cancer and the Immortal Strand Hypothesis.Genetics 2006 174: 1069-1072. doi:10.1534/genetics.104.66886
7: Bell CD. Is mitotic chromatid segregation random? Histol Histopathol. 2005 Oct;20(4):1313-20. Review.
8: Bell CD. Symmetry applied to nuclear microanatomy: a review of gene function and cell differentiation. Histol Histopathol. 2004 Jan;19(1):291-8. Review.
9: Patkin EL. Epigenetic mechanisms for primary differentiation in mammalian embryos. Int Rev Cytol. 2002;216:81-129. Review.
癌症的表型逆转问题一向是癌症研究人员最关心的问题。有那些方式可以逆转癌症表型呢？
外周环境可以逆转部分癌症细胞的表型。
1: Mintz B, Illmensee K.Normal genetically mosaic mice produced from malignant teratocarcinoma cells [J].Proc Natl Acad Sci U S A. 1975, 72(9):3585-9.
2: Illmensee K, Mintz B.Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts [J]. Proc Natl Acad Sci U S A. 1976, 73(2):549-53.
3: Rosen P. On the reversibility of tumor cells.Med Hypotheses. 1981 May;7(5):615-20.
4: Kaiser HE. Biological viewpoints of neoplastic regression.In Vivo. 1994 Jan-Feb;8(1):155-65. Review.
5: Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells.Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):13985-90. Epub 2004 Aug 11. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14305.
6: Pierce GB, Arechaga J, Wells RS. Embryonic control of cancer.
Prog Clin Biol Res. 1986;226:67-77. Review.
7: Barrett JC. A National Institutes of Health Workshop Report. Cellular and molecular mechanisms for suppression and reversion of tumorigenicity. A Chemical Pathology Study Section workshop.Cancer Res. 1987 May 1;47(9):2514-20.
阻断癌基因可以部分逆转癌症表型。
1: Arvanitis C, Felsher DW. Conditional transgenic models define how MYC initiates and maintains tumorigenesis. Semin Cancer Biol. 2006 Aug;16(4):313-7. Epub 2006 Jul 21. Review.
2: Shachaf CM, Felsher DW. Rehabilitation of cancer through oncogene inactivation.Trends Mol Med. 2005 Jul;11(7):316-21. Review.
3: Felsher DW. Reversibility of oncogene-induced cancer.Curr Opin Genet Dev. 2004 Feb;14(1):37-42.
细胞融合可以逆转癌细胞表型：
1: Harris H. The analysis of malignancy by cell fusion: the position in 1988.Cancer Res. 1988 Jun 15;48(12):3302-6.
2: Handmaker SD. Hybridization of eukaryotic cells.Annu Rev Microbiol. 1973;27:189-204. Review.
器官再生能力与癌变概率相反，与逆转癌症概率成正比：
1: Prehn RT. Regeneration versus neoplastic growth. Carcinogenesis. 1997 Aug;18:1439-44.
2: Prehn RT. Immunosurveillance, regeneration and oncogenesis.Prog Exp Tumor Res. 1971;14:1-24. Review.
作者: cypress1975
| 以下网友留言只代表网友个人观点，不代表网站观点 | |||
Copyright 2000-2025 DXY.CN All Rights Reserved