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    最新研究发现使用抗抑郁剂与精子数目有较大相关性。

    由康奈尔医学中心的Peter Schlegel博士领导的这项研究对两名男性患者进行了为期两年的仔细监测。这两名男性接受了西酞普兰或舍曲林的治疗。随后发现，他们的精子数目明显下降，事实上接近于零。当停止使用抗抑郁药，他们的精子数目反弹至正常水平。研究者还在其他十几个病人身上也发现了这个现象，尽管不如这两例效果明显。

    抗抑郁剂的选择性5羟色胺再摄取抑制剂类包括了最常用的百忧解和赛乐特。以前的研究表明此类药物与射精和阳痿问题有关。选择性5羟色胺再摄取抑制剂与生育力之间有很强的关联，这种药能引起明显降低精子数量和活力。这个问题可能与支配输精管的神经受损有关。

    这项新研究结果敦促那些使用选择性5羟色胺再摄取抑制剂的男性要接受医生的密切随访以确定是否会带来这种副作用。在使用选择性5羟色胺再摄取抑制剂的男性患者中，可能有些正在考虑要孩子。这项实验结果对他们可能有重要意义。

    本周，康奈尔医学中心的在奥尔良举办的美国生殖医学会第62届年会上发布了这项研究结果。

Antidepressants Linked to Male Infertility
Date Published: Tuesday, October 24th, 2006

Researchers at New York’s Cornell Medical Center have found a major correlation between use of antidepressants and sperm count. Men who take selective serotonin reuptake inhibitors (SSRIs) are being urged to consult closely with their doctors in order to determine a proper course of action in light of the new study, the first of its kind. Cornell’s Peter Schlegel announced the results this week at the 62nd annual meeting of the American Society for Reproductive Medicine (ASRM) in New Orleans.

The Cornell study involved the careful monitoring of two male patients over the course of two years. Both men were treated with citalopram (Cipramil) or sertraline (Lustral) and were later found to have significantly decreased sperm counts; in fact, their sperm counts actually approached zero. Once taken off the antidepressants, both men’s sperm counts rebounded to normal levels. Researchers also found a similar connection in a dozen other patients, although not quite as dramatic as in the two featured cases.

The SSRI class of antidepressants includes the highly popular drugs Prozac and Seroxat. Previous research had linked SSRIs to issues with ejaculation and impotency, but the effect on sperm count and fertility has never been documented before. In his presentation to the ASRM, Dr. Schlegel said he found what he termed a “strong association” between SSRIs and fertility, claiming that the drugs caused a “severe deterioration” of both sperm counts and motility.

Dr. Schlegel believes that the problem may be connected to damage of the nerves in the vas deferens, the tube trusted with the task of delivering sperm to semen just before ejaculation. For male SSRI patients who may be considering starting or continuing a family, the results may have major ramifications.

http://www.newsinferno.com/archives/1279

编辑：蓝色幻想