调节性T细胞发育与转录因子Foxp3
转载请注明来自丁香园
| 发布日期: 2006-08-15 13:52 | 文章来源: 丁香园 |
关键词:
免疫学
转录因子/Foxp3
调节性T细胞
自身免疫病变
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点击次数： |
Field: Immunology
Article Title: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
Authors: Fontenot, JD;Rudensky, AY
Journal: NAT IMMUNOL
Volume: 6
Issue: 4
Page: 331-337
Q：Why do you think your paper is highly cited?
A：This is a review paper in one of the "super-hot" areas of immunology, and our laboratory has recently made significant contributions to this field. This particular field is both of fundamental interest and is also important for clinically relevant studies.
Q：Does it describe a new discovery or a new methodology that?s useful to others?
A：This review paper describes a central role transcription factor Foxp3 plays in the development and function of a crucial subset of T cells?so-called regulatory T cells?controlling autoimmunity, anti-tumor immunity, and immunity to infections. A series of studies performed in the laboratory by Jason Fontenot established a role for Foxp3 as regulatory T cell lineage specification factor and provided definitive answers to several outstanding issues in the field.
Most importantly, these studies unequivocally demonstrated that lack of regulatory T cells results in an early onset, highly aggressive, and fatal autoimmune pathology affecting multiple organs.
Q：Could you summarize the significance of your paper in layman's terms?
A：This review paper describes a central role transcription factor Foxp3 plays in development and function of a crucial subset of T cells controlling autoimmunity, anti-tumor immunity, and immunity to infections.
Q：How did you become involved in this research, and were any problems encountered along the way?
A：Our interest in regulatory T cell biology can be traced to a journal club on "historic papers" in immunology organized by first-year graduate students in the department. A heated discussion in one of these journal clubs discussing early work of Sir Peter Medawar* on neonatal tolerance precipitated our thinking and interest in the problem of "dominant tolerance".
It also coincided with Marc Gavin joining the lab at that time as a postdoctoral fellow and Marc was very interested in starting a new project on regulatory T cells. Another major event was identification of transcription factor Foxp3 by Fred Ramsdell and colleagues at the Bothell, Washington-based firm Celltech, who greatly helped us to jump-start Foxp3-related research.
The main problem we encountered was the very intense competition the massive amount of publication in these areas which resulted in a flood of data of varying quality being published in a rush.
Alexander Rudensky, Ph.D.
Professor, Department of Immunology, University of Washington
Investigator, Howard Hughes Medical Institute
University of Washington School of Medicine
Seattle, WA, USA
问：为什么您认为您的论文有很高的引用率？
答：这是一篇关于免疫学非常热点领域的回顾性论文，最近我们实验室对该领域做出了重要的贡献。这个特别的领域对基础及临床相关研究都是至关重要的。
问：论文记述了对其它领域有用的新发现或新的方法学吗？
答：这篇回顾性论文描述了转录因子Foxp3 在一个重要的T 细胞亚系—称为调节性T 细胞（控制自身免疫、抗肿瘤免疫及对感染的免疫）中的发展及功能上所起的关键性作用。由Jason Fontenot 在实验室所作出的一系列研究确立了Foxp3作为调节性T 细胞系特异性因子的作用，而且，为该领域的一些重要的问题提供了确切的答案。
尤其重要的是，这些研究一致揭示缺少调节性T 细胞将导致早发、富于进攻性及致命的影响多器官的自身免疫病变。
问：您能不能用通俗的语言总结一下这篇论文的意义？
答：这篇回顾性论文描述了转录因子Foxp3 在一个控制自身免疫、抗肿瘤免疫及感染免疫的关键的T 细胞亚系中所起的重要作用。
问：您是怎样开始从事这项研究的，在研究的过程中遇到了哪些问题？
答：我们对调节性T 细胞生物学兴趣可追溯到一年级研究生组织的关于免疫学方面的“历史上著名的论文”杂志俱乐部。 杂志俱乐部所讨论的一个热点话题就是Sir Peter Medawar*从事的早期关于新生耐受方面的工作，从而激发了我们对“优势耐受”这个问题的思考及兴趣。
它也同那时作为博士后同行身份参加的Marc Gavin想法不谋而合，Marc对发起关于调节性T 细胞的一项新计划非常感兴趣。另一个重要事件就是Fred Ramsdell和其同事在Bothell—Washington为基地的Celltech公司—鉴定了转录因子Foxp3，他们极大地帮助我们发起与Foxp3-相关的研究。
我们遇到的主要问题是由于这些领域强大的竟争而引发大量的出版物所导致的不同质量的资料短时间内大量涌现。
编辑：西门吹血
Article Title: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
Authors: Fontenot, JD;Rudensky, AY
Journal: NAT IMMUNOL
Volume: 6
Issue: 4
Page: 331-337
Q：Why do you think your paper is highly cited?
A：This is a review paper in one of the "super-hot" areas of immunology, and our laboratory has recently made significant contributions to this field. This particular field is both of fundamental interest and is also important for clinically relevant studies.
Q：Does it describe a new discovery or a new methodology that?s useful to others?
A：This review paper describes a central role transcription factor Foxp3 plays in the development and function of a crucial subset of T cells?so-called regulatory T cells?controlling autoimmunity, anti-tumor immunity, and immunity to infections. A series of studies performed in the laboratory by Jason Fontenot established a role for Foxp3 as regulatory T cell lineage specification factor and provided definitive answers to several outstanding issues in the field.
Most importantly, these studies unequivocally demonstrated that lack of regulatory T cells results in an early onset, highly aggressive, and fatal autoimmune pathology affecting multiple organs.
Q：Could you summarize the significance of your paper in layman's terms?
A：This review paper describes a central role transcription factor Foxp3 plays in development and function of a crucial subset of T cells controlling autoimmunity, anti-tumor immunity, and immunity to infections.
Q：How did you become involved in this research, and were any problems encountered along the way?
A：Our interest in regulatory T cell biology can be traced to a journal club on "historic papers" in immunology organized by first-year graduate students in the department. A heated discussion in one of these journal clubs discussing early work of Sir Peter Medawar* on neonatal tolerance precipitated our thinking and interest in the problem of "dominant tolerance".
It also coincided with Marc Gavin joining the lab at that time as a postdoctoral fellow and Marc was very interested in starting a new project on regulatory T cells. Another major event was identification of transcription factor Foxp3 by Fred Ramsdell and colleagues at the Bothell, Washington-based firm Celltech, who greatly helped us to jump-start Foxp3-related research.
The main problem we encountered was the very intense competition the massive amount of publication in these areas which resulted in a flood of data of varying quality being published in a rush.
Alexander Rudensky, Ph.D.
Professor, Department of Immunology, University of Washington
Investigator, Howard Hughes Medical Institute
University of Washington School of Medicine
Seattle, WA, USA
问：为什么您认为您的论文有很高的引用率？
答：这是一篇关于免疫学非常热点领域的回顾性论文，最近我们实验室对该领域做出了重要的贡献。这个特别的领域对基础及临床相关研究都是至关重要的。
问：论文记述了对其它领域有用的新发现或新的方法学吗？
答：这篇回顾性论文描述了转录因子Foxp3 在一个重要的T 细胞亚系—称为调节性T 细胞（控制自身免疫、抗肿瘤免疫及对感染的免疫）中的发展及功能上所起的关键性作用。由Jason Fontenot 在实验室所作出的一系列研究确立了Foxp3作为调节性T 细胞系特异性因子的作用，而且，为该领域的一些重要的问题提供了确切的答案。
尤其重要的是，这些研究一致揭示缺少调节性T 细胞将导致早发、富于进攻性及致命的影响多器官的自身免疫病变。
问：您能不能用通俗的语言总结一下这篇论文的意义？
答：这篇回顾性论文描述了转录因子Foxp3 在一个控制自身免疫、抗肿瘤免疫及感染免疫的关键的T 细胞亚系中所起的重要作用。
问：您是怎样开始从事这项研究的，在研究的过程中遇到了哪些问题？
答：我们对调节性T 细胞生物学兴趣可追溯到一年级研究生组织的关于免疫学方面的“历史上著名的论文”杂志俱乐部。 杂志俱乐部所讨论的一个热点话题就是Sir Peter Medawar*从事的早期关于新生耐受方面的工作，从而激发了我们对“优势耐受”这个问题的思考及兴趣。
它也同那时作为博士后同行身份参加的Marc Gavin想法不谋而合，Marc对发起关于调节性T 细胞的一项新计划非常感兴趣。另一个重要事件就是Fred Ramsdell和其同事在Bothell—Washington为基地的Celltech公司—鉴定了转录因子Foxp3，他们极大地帮助我们发起与Foxp3-相关的研究。
我们遇到的主要问题是由于这些领域强大的竟争而引发大量的出版物所导致的不同质量的资料短时间内大量涌现。
编辑：西门吹血
作者: Alexander Rudensky
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