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伦敦（路透社消息）－研究人员称，使用现代降压药和降脂药90天，即可显著降低心脏病发作风险。

一项最新的由辉瑞制药公司（Pfizer Inc）资助的，有19000名患者参加的研究显示，联合使用该公司旗下的降脂药Lipitor（立普妥，英文通用名：Atorvastatin，中文通用名：阿托伐他汀）和降压药Norvasc（络活喜，英文通用名：Amlodipine，中文通用名：氨氯地平），仅三个月便可使致死性和非致死性心血管事件发作风险降低53％。

这项最近在线发表于《欧洲心脏杂志》（European Heart Journal）上的文章，连同先前的ASCOT研究成果，揭示了现代药物可使心脏病发作风险下降一半。

该研究还提示，Lipitor与Norvasc联合应用的疗效比Lipitor与传统降压药β受体阻滞剂（beta-blocker）联合应用的疗效强三倍。

然而就在公布最新ASCOT正面报告的前一周末，辉瑞做出了一个重大决定，放弃一项名为torcetrapib的降脂新药的开发，并导致其生产线的主要空缺。

Lipitor是世界上销售量最大的药物，但将于2011年失去美国专利保护，因此辉瑞急需开发有影响力的新药以维持其销售量。

Modern drugs cut heart attack risk within 90 days
Mon Dec 4, 2006 3:06am ET

LONDON (Reuters) - Patients taking modern blood pressure and cholesterol drugs significantly reduce their risk of suffering a heart attack within 90 days of starting treatment, researchers said on Monday.

New analysis from a 19,000-patient study sponsored by Pfizer Inc showed its cholesterol drug Lipitor used alongside its anti-hypertensive Norvasc reduced the risk of fatal and non-fatal cardiac events by 53 percent, with the benefits evident after only three months.

The results, published online in the European Heart Journal, are the latest in a batch of findings from the so-called ASCOT study to highlight the fact that modern medicines can half the risk of heart attacks.

The new data also showed Lipitor plus Norvasc was about three times more effective at preventing heart attacks than Lipitor plus a beta-blocker, an older type of blood pressure drug.

PFIZER SCRAPS NEW DRUG

However, the positive ASCOT news emerged just after Pfizer dropped a bombshell at the weekend, when it scrapped development of a new kind of anti-cholesterol drug called torcetrapib, leaving a major hole in its product pipeline.

Lipitor is the world's biggest-selling medicine but it loses U.S. patent protection in 2011, after which Pfizer needs new blockbusters to keep its sales line growing.

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http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2006-12-04T111358Z_01_L03228642_RTRUKOC_0_US-HEART-DRUGS.xml&WTmodLoc=HealthNewsHome_C1_%5bFeed%5d-4

编辑：蓝色幻想