根据12月份《PLoS医学》的一篇文章报道，瑞士研究人员称局部应用从公鸡冠中提取的透明质酸盐（HA）对于治疗老年性皮肤萎缩患者有效。
首席研究员日内瓦大学的Gurkhan Kaya 博士在接受路透社健康新闻记者采访时说：“我们已经分离出了一种HA来源的皮肤抗萎缩因子，其抗萎缩机制与CD44-HA通路有关。”他和他的同事们注意到细胞对HA的反应主要由其主细胞表面的受体CD44 所介导。在体外和小鼠体内的实验中，该研究小组证实了这个事实。CD44功能缺陷似乎是皮肤萎缩发病的基础。
研究人员随后研究了6名平均年龄为76岁的皮肤萎缩患者和17名年龄在19到65岁之间的健康对照。他们每日在受试者前臂涂抹大量1%纯度的透明质酸盐碎末，为期一个月。在疗程结束时，对照组无一出现皮肤增厚、炎症或瘢痕的征象。然而，所有皮肤萎缩患者病情表现都有所改善。这些情况通过皮肤厚度以及假瘢痕、出血和可见的表浅血管消失进行量化评分。
Kaya博士总结说：“该因子与老年人皮肤极度萎缩有关。”然而，他补充到，HA因子“与其他专门干扰该（CD44-HA）通路的分子联合应用可能会对年轻人预防皮肤萎缩有效。”
Hyaluronate Reverses Skin Atrophy in the Elderly
By David Douglas
NEW YORK (Reuters Health) Dec 28 - Topical application of hyaluronate (HA) derived from rooster comb appears to be effective in treating skin atrophy in elderly patients, Swiss researchers report in the December issue of PLoS Medicine.
"We have identified a HA-derived skin anti-atrophy factor and its anti-atrophy mechanisms related to the CD44-HA pathway," lead investigator Dr. Gurkhan Kaya told Reuters Health.
Dr. Kaya of the University of Geneva and colleagues note that cellular responses to HA are primarily mediated by its principal cell surface receptor CD44. In vitro and in mice, the team established that this was the case. Defective CD44 functioning appears to underlie the pathogenesis of atrophy.
The researchers then studied 6 patients with a mean age of 76 years who had atrophic skin lesions and 17 healthy controls ranging in age from 19 to 65 years.
They were given daily treatment on the forearm with a 1% preparation of large hyaluronate fragments for one month. At the end of the treatment period, none of the control group demonstrated signs of skin thickening, inflammation or scaling.
However, all of the patients with skin atrophy showed improvement. This was characterized by marked skin thickening and the disappearance of pseudoscars, hemorrhage and visible superficial vessels.
"This factor corrects the extreme skin atrophy of elderly people," concluded Dr. Kaya.
However, he added, the combination of the HA factor "with other molecules which specifically interfere with the (CD44-HA) pathway may be of use for preventing skin atrophy in younger individuals."
PLoS Med 2006;3.
作者: luohui961 译
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