dxy

在严重营养不良儿童中核苷酸摄取和营养恢复对胰岛素样生长因子-1和其它激素生物标记的影响
by hummingbirds

这项研究的目的是证实在严重营养不良儿童中核苷酸摄取和加强的营养支持对胰岛素样生长因子-1（IGF-I）和其它激素生物标记浓度的影响。26个严重营养不良的儿童（<48个月）接受了2周不含乳糖的经肠道喂养和附加2周随意喂养的治疗。执行人体测量，获得了胰岛素样生长因子-1、胰岛素样生长因子连接蛋白-3（IGFBP-3）、瘦素、可溶性瘦素受体（sOB-R）的血清浓度和可溶性瘦素受体超过瘦素的估计摩尔量。分为两组，每组13人，一组治疗补充核苷酸（NT+），另一组治疗未补充核苷酸（NT-）。对照组13人。使用参数检验、非参数检验以及ANOVA分析。营养恢复、核苷酸摄取、营养不良的类型、年龄、性别与营养不良的相互作用影响胰岛素样生长因子-1的浓度（P<0.001）。营养恢复、核苷酸摄取、性别与营养不良的相互作用影响胰岛素样生长因子连接蛋白-3的浓度（P<0.001）。营养恢复对血清瘦素有明显影响（P=0.001）。年龄和营养恢复对可溶性瘦素受体有影响（P<0.001）；所有包括的变量影响可溶性瘦素受体超过瘦素的摩尔量（P<0.001）。总之，核苷酸摄取和营养恢复对胰岛素样生长因子-1、胰岛素样生长因子连接蛋白-3和其它激素生物标记有显著影响。这个结果能够激励严重营养不良的婴儿和初学走路的孩子在营养恢复期跟上生长发育。

出处：Br J Nutr. 2006 Oct;96(4):683-690.

Effect of nucleotide intake and nutritional recovery on insulin-like growth factor I and other hormonal biomarkers in severely malnourished children.

The objective of the present study is to demonstrate the effect of nucleotide intake and intensive nutritional support on the concentration of insulin-like growth factor I (IGF-I) and other hormonal biomarkers in severely malnourished children. Twenty-six severely malnourished children <48 months of age received formula without lactose via enteral feeding for 2 weeks and ad libitum for an additional 2 weeks. Anthropometrical measurements were performed and serum concentrations of IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3), leptin, soluble leptin receptor (sOB-R), as well as the estimated molar excess of sOB-R over leptin were obtained. Two groups were formed. One group received formula with nucleotides (NT+; n 13) and the other without nucleotides (NT-; n 13). A control group was included (n 13). Parametric and non-parametric tests as well as ANOVA models were used. Nutritional recovery, nucleotides intake, type of malnutrition, age and the interaction between gender and malnutrition influenced the concentration of IGF-I (P<0.001). Nutritional recovery, nucleotides intake, gender and type of malnutrition had an effect on IGFBP-3 (P<0.001). Nutritional recovery had a significant effect on serum leptin (P=0.001). Age and nutritional recovery had an effect on sOB-R (P<0.001); all variables included affected the molar excess of sOB-R over leptin (P<0.001). In conclusion, nucleotide intake and nutritional recovery had a notable effect on IGF-I, IGFBP-3 and other hormonal biomarkers. This outcome could stimulate the catch-up growth of severely malnourished infants and toddlers during the nutritional recovery period.

PMID: 17010227

限制高质量蛋白摄入的低能量饮食对泌乳大鼠的代谢影响
by lifengatongmu

怀孕期对成年雌性SD大鼠进行随意喂养，哺乳期时节制饮食（节制饮食；16.1 kJ/g）或者进行以小麦谷蛋白为主要蛋白来源的低能量饮食（低能量饮食；13.3 kJ/g）。体重，食物摄入，静息时能量消耗（量），呼吸商和经乳腺利用的底物先被测量出来。这些动物被杀后，对子宫旁组织和腹膜后的脂肪垫进行称重。两组大鼠的平均摄入量是相似的，以致低能量饮食大鼠摄取较低能量后，在持续2周哺乳期内出现显著差异。从哺乳期第9天起，低能量饮食组中dams和pups的平均体重较低。而在节制饮食组中静息时能量消耗（量）在哺乳期间是逐渐增加的，且在哺乳期持续几周内，这种增加并没有在低能量饮食组中看到。前一夜已经禁食的大鼠呼吸商为0.7甚至更小，而至于被给食的大鼠平均呼吸商则超过了1.0。在这两种情况下，大鼠均显示出酮尿。动静脉的3-羟基丁酸盐浓度差别比较高，而那些通过低能量饮食的大鼠，其乳腺的葡萄糖、乳酸盐以及三酰基甘油都比较低。低能量饮食大鼠子宫旁组织的脂肪库称量也较小。所以减少静息时能量消耗(量)的这种增加而使用酮体作为燃料，在一定程度上可能表示，低能量饮食dams的重要机制掩盖了乳制品的能量价值。

出处：Br J Nutr. 2006 Oct;96(4):667-73.

Some metabolic effects on lactating rats of a low-energy diet restricted in good-quality protein.

Adult female Sprague-Dawley rats were fed ad libitum during pregnancy and lactation a control diet (CD; 16.1 kJ/g) or a low-energy diet with wheat gluten as the main protein source (LED; 13.3 kJ/g). Body weight, food intake, resting energy expenditure, respiratory quotient and substrate use by the mammary gland were measured. After the animals had been killed, the parametrial and retroperitoneal fat pads were weighed. The mean food intake (g) of the two groups of rats was similar, resulting in a lower energy intake by the LED rats, significantly different during the last 2 weeks of lactation. The mean body weight of both dams and pups in the LED group was lower, starting at day 9 of lactation. The resting energy expenditure increased gradually during lactation in the control group, whereas this increase was not seen in rats of the LED group in the last week of lactation. Rats that had fasted overnight had a respiratory quotient of 0.7 or less, whereas for rats that had been fed, the mean respiratory quotient was over 1.0. Under both conditions, rats showed ketonuria. The arteriovenous difference in 3-hydroxybutyrate level was higher and those for glucose, lactate and triacylglycerol were lower across the mammary glands of LED rats. The parametrial fat depot weighed less in LED rats. Reducing the increase in resting energy expenditure and using ketone bodies to a greater extent as fuels may represent important mechanisms in the LED dams to cover the energy cost of milk production.

PMID: 17010225

年龄在6-15岁间的希腊健康学童的总血清高半胱氨酸的参考范围与饮食指标
by lifengatongmu

提高总血清高半胱氨酸（tHcy）可能是心血管疾病的一个危险因子。成人中总血清高半胱氨酸每提高5mu mol/l，心血管疾病的相对危险性就会提高70%。但是所得儿童和青少年的资料有限。当前研究的目的为总血清高半胱氨酸提供一个参考范围，并调查希腊儿科人群的总血清高半胱氨酸与营养指数间的关系。测量520个（274个男孩，246个女孩）年龄在6-15岁间健康学童的总血清高半胱氨酸，叶酸，维生素B12浓度和饮食指数。同样在成人，总血清高半胱氨酸分布倾向右侧，两性几何平均数为7.4（范围：3.4-29mumol/l）。在幼儿中浓度较低并随年龄增长。两性总血清高半胱氨酸浓度没有观察到显著的统计学差异。95%分三个年龄组如下：6-9岁，9.98 mumol/l；10-12岁，10.62 mumol/l；13-15岁，14.4 mumol/l。使用皮尔森系数分析，总血清高半胱氨酸浓度与年龄、血清叶酸盐、体重指数和收缩压相关。食谱分析显示，叶酸盐、维生素B12和纤维摄取与总血清高半胱氨酸反相关。相反地，糖和脂肪与总血清高半胱氨酸紧密关联。然而，用多次线性回归分析仅仅年龄（优势比0.246，P<0.05）和叶酸盐（优势比-0.346，P<0.05）显著而独立地与总血清高半胱氨酸有关。这个研究提供了在希腊儿科人群中以年龄分组的有关总血清高半胱氨酸的参考数据。总血清高半胱氨酸浓度由于年龄的机能而增加。血清叶酸盐浓度显著而独立地与总血清高半胱氨酸浓度关联。

出处：Br J Nutr. 2006 Oct;96(4):719-24.

Reference range of total serum homocysteine level and dietary indexes in healthy Greek schoolchildren aged 6-15 years.

Elevated total serum homocysteine (tHcy) may be a possible risk factor for CVD. A 5 mumol/l increase in tHcy is associated with an approximately 70 % increase in relative risk of CVD in adults. Data for children and adolescents are, however, limited. The purpose of the present study was to provide a reference range for tHcy and investigate any relationship between tHcy and nutritional indexes in a Greek paediatric population. tHcy, folate, vitamin B12 levels and dietary indexes were measured in 520 healthy schoolchildren (274 boys, 246 girls) aged 6-15 years. As in adults, the tHcy distribution skewed to the right, with a geometric mean for both genders of 7.4 (range 3.4-29 mumol/l). Concentrations were lower in young children and increased with age. No statistically significant difference in tHcy level was observed between gender. The 95th percentiles for the three age groups were as follows: 6-9 years, 9.98 mumol/l; 10-12 years, 10.62 mumol/l; 13-15 years, 14.4 mumol/l. Using Pearson's coefficient analysis, tHcy level was correlated with age, serum folate, BMI and systolic blood pressure. Dietary analysis showed that folate, vitamin B12 and fibre intake were inversely related with tHcy; conversely, sugar and fat were positively associated with tHcy. However, in multiple linear regression analysis, only age (odds ratio 0.246, P<0.05) and folate (odds ratio -0.346, P<0.05) were significantly and independently associated with tHcy. This study provides age-specific reference data regarding tHcy concentration in a Greek paediatric population. tHcy levels increased as a function of age. Serum folate levels were significantly and independently associated with tHcy levels.

PMID: 17010232


编辑：bluelove