第73届美国糖尿病协会科学年会

ADA2013:同济大学医学院曲伸教授发现T2DM患者骨钙蛋白可改善血糖控制

作者:desperado-c    2013-07-03
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为了探讨在中国2型糖尿病(T2DM)患者中,血清骨钙蛋白与血糖控制、胰腺功能和胰岛素敏感性的关系。来自同济大学医学院的曲伸教授及其团队进行了一项研究,该研究发现在T2DM患者中,骨钙蛋白与血糖呈负相关。

该研究中,招募了1019例T2DM患者(男性:432例,女性:587例,平均年龄:65.96±13.11岁)。测量后确定体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、空腹C肽(F-CP)、餐后血糖(2hPBG)、餐后C肽(2hC-P)、糖化血红蛋白(HbA1c)、以及骨钙蛋白。根据上述参数计算稳态模型评估的β细胞功能(HOMA-β)和稳态模型评估的胰岛素抵抗(HOMA-IR)。

该研究结果表明,男性和女性之间的骨钙蛋白水平有显著差异[(13.51±12.37)ng/ml vs (16.22±10.40)ng/ml,P<0.001]。校正年龄和BMI后,血清骨钙蛋白与HbA1c、FPG和2hPBG呈负相关(P<0.05),并与FC-P、2hC-P和HOMA-β呈正相关(P<0.05)。在男性患者,校正年龄和BMI后,血清骨钙蛋白与2hPBG呈负相关(P<0.05),并与FC-P、2hC-P和HOMA-β呈正相关(P<0.05)。在女性,校正年龄和BMI后,血清骨钙蛋白与HbA1c、FPG呈负相关(P<0.05)。多元线性回归分析显示,在男性,血清骨钙蛋白是影响HOMA-β和HOMA-IR的独立相关因素,并且,在所有受试者中,血清骨钙蛋白也是影响HOMA-IR的独立相关因素(P<0.05)。

该研究发现,在T2DM患者,骨钙蛋白与血糖呈负相关,暗示骨钙蛋白可以降低血糖。并且,骨钙蛋白与FC-P、2hC-P和HOMA-β呈正相关,支持骨钙蛋白可以通过促进胰岛的胰岛素分泌,改善血糖控制的观点。

 

This study is to investigate the association between serum osteocalcin and glucose control pancreatic function and insulin sensitivity in the type 2 diabetes mellitus (T2DM) Chinese patients.

1019 T2DM patients were recruited (Male:432 Female:587 Average age: 65.96 ± 13.11 years). After measured BMI the fasting plasma glucose(FPG) insulin(FINS) C peptide(F-CP) postprandial blood glucose (2hPBG) and C peptide (2hC-P) HbA1C and osteocalcin were determined. Homeostasis model assessment of β cell function (HOMA-β) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated based on the above parameters.

The difference in osteocalcin levels between male and female are significant [(13.51±12.37)ng/mL vs (16.22±10.40)ng/mL P<0.001]. After adjustment for age and BMI serum osteocalcin was negatively correlated with HbA1C FPG and 2hPBG (P<0.05) and positively correlated with fasting C peptide (FC-P) 2h C peptide (2hC-P) and HOMA-β (P<0.05). In male after adjustment for age and BMI serum osteocalcin was negatively correlated with 2hPBG (P<0.05) and positively correlated with FC-P 2hC-P and HOMA-β (P<0.05). In female after adjustment for age and BMI serum osteocalcin was negatively correlated with HbA1C FPG (P<0.05). Multivariable liner regression analysis showed that serum osteocalcin was the independent related factor in influencing HOMA-β and HOMA-IR in male and it was also the independent related factor in influencing HOMA-IR in all subjects (P<0.05).

In T2DM osteocalcin was negatively associated with glucose implying osteocalcin could lower blood glucose. And osteocalcin was positively associated with FC-P 2hC-P and HOMA-β supporting the idea that osteocalcin might improve glucose control through promoting insulin secretion of pancreatic islet.

 

编辑: 葛根    来源:丁香园

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ADA是美国糖尿病学会 (Americn Diabetos Association)的缩写,美国糖尿病协会县美国重要的非赢利性卫生姐织,旨在提供有关糖尿病的研究进展和信息,促进糖尿病的科研、教育、诊疗等,关注一切与糖尿病有关的事务。