ADA2013：同济大学医学院曲伸发现25羟维生素D可改善血糖控制

为了评估在中国2型糖尿病患者中，25羟维生素D[25(OH)D]的状态，以及其与葡萄糖代谢的关系。来自同济大学医学院的曲伸教授及其团队进行了一项研究，该研究发现维生素D缺乏在中国糖尿病人群中非常普遍。25(OH)D水平与血糖和稳态模型评估的胰岛素抵抗（HOMA–IR）呈负相关，暗示25(OH)D可以通过改善胰岛素抵抗降低血糖。

该研究中，在一个来自中国上海、被诊断为2型糖尿病的患者的横断面样本（592例男性和543例女性，年龄30–80岁）中测量血浆25(OH)D。测量空腹血糖、空腹胰岛素、糖化血红蛋白（HbA1c）。根据上述参数计算稳态模型评估的β细胞功能（HOMA–β）和HOMA–IR。

该研究结果表明，血浆25(OH)D的几何均数为52nmol/l，且维生素D缺乏[25(OH)D＜50nmol/l]和维生素D不足[50nmol/l≤25(OH)D＜75nmol/l]的比例分别为53.1%和25.8%。25(OH)D与HbA1c、空腹血糖和HOMA-IR呈显著负相关（r=-0.066,p＜0.05; r=-0.122,p＜0.01; r=-0.091,p＜0.01）。

该研究发现，维生素D缺乏在中国糖尿病人群中非常普遍。25(OH)D水平与血糖和HOMA-IR呈负相关，暗示25(OH)D可以通过改善胰岛素抵抗降低血糖。需要前瞻性随机临床试验确定25(OH)D在调节葡萄糖代谢中的作用。

To evaluate the status of 25-hydroxyvitamin D [25(OH)D] and its association with glucose metabolism in the type two diabetes Chinese patients.

Plasma 25(OH)D was measured in a cross-sectional sample of 592 men and 543 women aged 30-80 years from Shanghai Chinese patients who have been diagnosed with type two diabetes mellitus. Fasting plasma glucose insulin A1C were measured. Homeostasis model assessment of β cell function (HOMA-β) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated based on the above parameters.

The geometric mean of plasma 25(OH)D was 52 nmol/l and percentages of vitamin D deficiency [25(OH)D <50 nmol/l] and insufficiency [50 ≤ 25(OH)D <75 nmol/l] were 53.1% and 25.8% respectively. Significant inverse associations existed between 25(OH)D with A1C and fasting plasma glucose and HOMA-IR(r=-0.066 p<0.05; r=-0.122 p<0.01; r=-0.091 p<0.01).

Vitamin D deficiency is common in diabetic Chinese population. 25(OH)D level is significantly negatively associated with plasma glucose and HOMA-IR implying 25(OH)D might lower glucose through improve insulin resistance . Prospective randomized clinical trials are warranted to determine the role of 25(OH)D in regulating glucose metabolism.

编辑： 葛根    来源：丁香园