Jiang Liu
Jiang Liu
Our group is trying to integrate genomics method to understand some fundamental questions in epigenetic inheritance, animal development and cancer pathogenesis. We revealed that sperm DNA methylome is inherited by early embryos in zebrafish, and both maternal and paternal DNA methylome undergo active demethylation during early embryogenesis in mammals. We also found that hypoxia can drive SPOP mislocation in cytoplasm, which can degrade PTEN and promote kidney tumorigenesis.