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Web of Science中有关RNAi的被引频次最多的十篇文献
（其中第二篇为Fire与 Mello的论文）

Record 1 of 10
Elbashir, SM; Harborth, J; Lendeckel, W; Yalcin, A; Weber, K; Tuschl, T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. NATURE 411 (6836): 494-498.
Times Cited: 2635

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Record 2 of 10
Fire, A; Xu, SQ; Montgomery, MK; Kostas, SA; Driver, SE; Mello, CC. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. NATURE 391 (6669): 806-811.
Times Cited: 2517

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Record 3 of 10
Hannon, GJ. 2002. RNA interference. NATURE 418 (6894): 244-251.
Times Cited: 1075

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Record 4 of 10
Bernstein, E; Caudy, AA; Hammond, SM; Hannon, GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. NATURE 409 (6818): 363-366.
Times Cited: 926

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Record 5 of 10
Elbashir, SM; Lendeckel, W; Tuschl, T. 2001. RNA interference is mediated by 21-and 22-nucleotide RNAs. GENES & DEVELOPMENT 15 (2): 188-200.
Times Cited: 900

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Record 6 of 10
Hammond, SM; Bernstein, E; Beach, D; Hannon, GJ. 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. NATURE 404 (6775): 293-296.
Times Cited: 807

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Record 7 of 10
Zamore, PD; Tuschl, T; Sharp, PA; Bartel, DP. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. CELL 101 (1): 25-33.
Times Cited: 786

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Record 8 of 10
Volpe, TA; Kidner, C; Hall, IM; Teng, G; Grewal, SIS; Martienssen, RA. 2002. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. SCIENCE 297 (5588): 1833-1837.
Times Cited: 552

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Record 9 of 10
Kamath, RS; Fraser, AG; Dong, Y; Poulin, G; Durbin, R; Gotta, M; Kanapin, A; Le Bot, N; Moreno, S; Sohrmann, M; Welchman, DP; Zipperlen, P; Ahringer, J. 2003. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. NATURE 421 (6920): 231-237.
Times Cited: 547

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Record 10 of 10
Fraser, AG; Kamath, RS; Zipperlen, P; Martinez-Campos, M; Sohrmann, M; Ahringer, J. 2000. Functional genomic analysis of C-elegans chromosome I by systematic RNA interference. NATURE 408 (6810): 325-330.
Times Cited: 531

Web of Science中有关RNAi的文献在
BIOCHEMISTRY & MOLECULAR BIOLOGY领域中被引频次最多的五篇文献

（*Web of Science按期刊进行学科分类，因而一本期刊可以被同时分在两个以上的学科当中，相应期刊中的文献也可同时被分在两个以上的学科当中。另由于Fire和Mello1998年的论文发表在Nature上，而Nature被分在MULTIDISCIPLINARY SCIENCES之列。）

Record 1 of 5
Zamore, PD; Tuschl, T; Sharp, PA; Bartel, DP. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. CELL 101 (1): 25-33.
Times Cited: 786

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Record 2 of 5
Elbashir, SM; Martinez, J; Patkaniowska, A; Lendeckel, W; Tuschl, T. 2001. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO JOURNAL 20 (23): 6877-6888.
Times Cited: 462

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Record 3 of 5
Tabara, H; Sarkissian, M; Kelly, WG; Fleenor, J; Grishok, A; Timmons, L; Fire, A; Mello, CC. 1999. The rde-1 gene, RNA interference, and transposon silencing in C-elegans. CELL 99 (2): 123-132.
Times Cited: 458

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Record 4 of 5
Grishok, A; Pasquinelli, AE; Conte, D; Li, N; Parrish, S; Ha, I; Baillie, DL; Fire, A; Ruvkun, G; Mello, CC. 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C-elegans developmental timing. CELL 106 (1): 23-34.
Times Cited: 431

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Record 5 of 5
Elbashir, SM; Harborth, J; Weber, K; Tuschl, T. 2002. Analysis of gene function in somatic mammalian cells using small interfering RNAs. METHODS 26 (2): 199-213.
Times Cited: 402