dxy

A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status,N Engl J Med 2005;353:2271-2280, November 24, 2005.

A gross external photograph of the brain shows that the left temporal, parietal, and anterior occipital lobes are soft and yellow (arrows, Panel A).

A coronal section of the left cerebral hemisphere shows laminar cortical disruption in the inferior parietal lobule and lateral temporal cortexes (arrows, Panel ).

A low-magnification photomicrograph of the left superior and middle temporal gyri reveals laminated cortical disruption (arrows, Panel C).

Marked neuronal loss, reactive gliosis, and the accumulation of hemosiderin-laden macrophages are seen on higher magnification (inset). Some cerebellar Purkinje cells have marked swelling of the proximal dendrites, the so-called “cactus dendrites” (arrows, Panel D). (Panels C and D, Luxol fast blue– hematoxylin and eosin stain).

图上面为A B，下面为C D。

MELAS病

A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status,N Engl J Med 2005;353:2271-2280, November 24, 2005.

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编辑：西门吹血