Victor Ambros：发育与疾病的microRNA调控途径
MicroRNA regulatory pathways in development and disease
Victor Ambros
（University of Massachusetts Medical School, USA）
miRNA的发现者，2008 Lasker 奖获得者Victor Ambros
We employ the nematode worm C. elegans as a model experimental system for studying the genetic mechanisms underlying the control of animal development and human disease. The study of worm mutants with developmental defects has led to the identification of genes that encode regulators of developmental and physiological processes important to all animals. Some of these regulatory genes encode a class of small RNAs, known as microRNAs that regulate the production of protein from the messenger RNAs of specific target genes. MicroRNAs are evolutionarily ancient, and some of the same microRNAs that function in C. elegans development are also present in humans, where they appear to regulate processes related to diseases such as cancer, diabetes, and neural degenerative diseases.
Our work includes exploring the functions of microRNA regulatory pathways in these human diseases, through the analysis of microRNA expression in clinical samples, and the application of mammalian cell and C. elegans genetic models.
Victor Ambros：发育与疾病的microRNA调控途径
Victor Ambros：发育与疾病的microRNA调控途径
Victor Ambros：发育与疾病的microRNA调控途径
Victor Ambros：发育与疾病的microRNA调控途径
Victor Ambros：发育与疾病的microRNA调控途径
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