癌症研究历史经典回顾和热点寻踪（二）
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第一个病毒癌基因的发现：Duesberg PH是发现者之一。
1: Duesberg PH, Vogt PK. Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses.Proc Natl Acad Sci U S A. 1970 Dec;67(4):1673-80.
2: Martin GS, Duesberg PH. The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants.Virology. 1972 Feb;47(2):494-7.
3: Lai MM, Duesberg PH, Horst J, Vogt PK. Avian tumor virus RNA: a comparison of three sarcoma viruses and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridization.Proc Natl Acad Sci U S A. 1973 Aug;70:2266-70.
4: Duesberg PH, Kawai S, Wang LH, Vogt PK, Murphy HM, Hanafusa H. RNA of replication-defective strains of Rous sarcoma virus.Proc Natl Acad Sci U S A. 1975 Apr;72(4):1569-73.
第一个细胞癌基因（原癌基因）的发现，为此美国人Varmus HE, Bishop JM获得1989年诺贝尔奖，方法就是博士后法国人Stehelin D用了半年时间制造基因探针，只是杂交了一下正常鸡的组织，发现了病毒的癌基因竟然也存在于正常动物组织之中，由此解开了癌基因理论的序幕。为此法国人Stehelin D要求他也应当获得诺贝尔奖，并要打官司。Duesberg 认为应当有资格获得诺贝尔奖的还有Hidesabuo Hanafusa 和 Peter Vogt 以及他自己，还有Robert Weinberg.
Stehelin D, Varmus HE, Bishop JM, Vogt PK. DNA related to the transforming gene of avian sarcoma viruses is present in normal avian DNA.Nature. 1976 Mar 11;260(5547):170-3.
第一个证明细胞癌基因具有致瘤能力的实验，Robert Weinberg实验室开始的。
1: Shih C, Shilo BZ, Goldfarb MP, Dannenberg A, Weinberg RA. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.Proc Natl Acad Sci U S A. 1979 Nov;76(11):5714-8.
PMID: 230490 [PubMed - indexed for MEDLINE]
2: Shih C, Padhy LC, Murray M, Weinberg RA. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts.Nature. 1981 Mar 19;290(5803):261-4.
3: Shilo BZ, Weinberg RA. Unique transforming gene in carcinogen-transformed mouse cells. Nature. 1981 Feb 12;289(5798):607-9. PMID: 6258087 [PubMed - indexed for MEDLINE]
20世纪70年代末80年代初，癌基因理论获得巨大的实验支持，主要文献见：
1: Weinberg RA. Oncogenes of spontaneous and chemically induced tumors.Adv Cancer Res. 1982;36:149-63. Review. No abstract available.
PMID: 6751037 [PubMed - indexed for MEDLINE]
2: Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis.Science. 1983 Nov 18;222(4625):771-8. Review.
PMID: 6356358 [PubMed - indexed for MEDLINE]
3: Friend SH, Dryja TP, Weinberg RA. Oncogenes and tumor-suppressing genes.N Engl J Med. 1988 Mar 10;318(10):618-22. Review.
4: Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.Cancer Res. 1989 Jul 15;49(14):3713-21. Review.
5: Bishop JM. Cellular oncogenes and retroviruses.Annu Rev Biochem. 1983;52:301-54. Review. .
PMID: 6351725 [PubMed - indexed for MEDLINE]
6: Bishop JM. The molecular genetics of cancer.Science. 1987 Jan 16;235(4786):305-11. Review.
PMID: 3541204 [PubMed - indexed for MEDLINE]
7: Bishop JM. Molecular themes in oncogenesis.
Cell. 1991 Jan 25;64(2):235-48. Review.
PMID: 1988146 [PubMed - indexed for MEDLINE]
8: Varmus HE. The molecular genetics of cellular oncogenes.Annu Rev Genet. 1984;18:553-612. Review. .
PMID: 6397126 [PubMed - indexed for MEDLINE]
9: Varmus HE. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia.Cancer. 1985 May 15;55(10):2324-8. Review.
PMID: 2985231 [PubMed - indexed for MEDLINE]
1: Duesberg PH, Vogt PK. Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses.Proc Natl Acad Sci U S A. 1970 Dec;67(4):1673-80.
2: Martin GS, Duesberg PH. The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants.Virology. 1972 Feb;47(2):494-7.
3: Lai MM, Duesberg PH, Horst J, Vogt PK. Avian tumor virus RNA: a comparison of three sarcoma viruses and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridization.Proc Natl Acad Sci U S A. 1973 Aug;70:2266-70.
4: Duesberg PH, Kawai S, Wang LH, Vogt PK, Murphy HM, Hanafusa H. RNA of replication-defective strains of Rous sarcoma virus.Proc Natl Acad Sci U S A. 1975 Apr;72(4):1569-73.
第一个细胞癌基因（原癌基因）的发现，为此美国人Varmus HE, Bishop JM获得1989年诺贝尔奖，方法就是博士后法国人Stehelin D用了半年时间制造基因探针，只是杂交了一下正常鸡的组织，发现了病毒的癌基因竟然也存在于正常动物组织之中，由此解开了癌基因理论的序幕。为此法国人Stehelin D要求他也应当获得诺贝尔奖，并要打官司。Duesberg 认为应当有资格获得诺贝尔奖的还有Hidesabuo Hanafusa 和 Peter Vogt 以及他自己，还有Robert Weinberg.
Stehelin D, Varmus HE, Bishop JM, Vogt PK. DNA related to the transforming gene of avian sarcoma viruses is present in normal avian DNA.Nature. 1976 Mar 11;260(5547):170-3.
第一个证明细胞癌基因具有致瘤能力的实验，Robert Weinberg实验室开始的。
1: Shih C, Shilo BZ, Goldfarb MP, Dannenberg A, Weinberg RA. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.Proc Natl Acad Sci U S A. 1979 Nov;76(11):5714-8.
PMID: 230490 [PubMed - indexed for MEDLINE]
2: Shih C, Padhy LC, Murray M, Weinberg RA. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts.Nature. 1981 Mar 19;290(5803):261-4.
3: Shilo BZ, Weinberg RA. Unique transforming gene in carcinogen-transformed mouse cells. Nature. 1981 Feb 12;289(5798):607-9. PMID: 6258087 [PubMed - indexed for MEDLINE]
20世纪70年代末80年代初，癌基因理论获得巨大的实验支持，主要文献见：
1: Weinberg RA. Oncogenes of spontaneous and chemically induced tumors.Adv Cancer Res. 1982;36:149-63. Review. No abstract available.
PMID: 6751037 [PubMed - indexed for MEDLINE]
2: Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis.Science. 1983 Nov 18;222(4625):771-8. Review.
PMID: 6356358 [PubMed - indexed for MEDLINE]
3: Friend SH, Dryja TP, Weinberg RA. Oncogenes and tumor-suppressing genes.N Engl J Med. 1988 Mar 10;318(10):618-22. Review.
4: Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.Cancer Res. 1989 Jul 15;49(14):3713-21. Review.
5: Bishop JM. Cellular oncogenes and retroviruses.Annu Rev Biochem. 1983;52:301-54. Review. .
PMID: 6351725 [PubMed - indexed for MEDLINE]
6: Bishop JM. The molecular genetics of cancer.Science. 1987 Jan 16;235(4786):305-11. Review.
PMID: 3541204 [PubMed - indexed for MEDLINE]
7: Bishop JM. Molecular themes in oncogenesis.
Cell. 1991 Jan 25;64(2):235-48. Review.
PMID: 1988146 [PubMed - indexed for MEDLINE]
8: Varmus HE. The molecular genetics of cellular oncogenes.Annu Rev Genet. 1984;18:553-612. Review. .
PMID: 6397126 [PubMed - indexed for MEDLINE]
9: Varmus HE. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia.Cancer. 1985 May 15;55(10):2324-8. Review.
PMID: 2985231 [PubMed - indexed for MEDLINE]
作者: cypress1975
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