奥司他韦在治疗H5N1感染过程中的耐药性问题
Title: Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection
Author: de Jong, MD; Thanh, TT; Khanh, TH, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 353 Issue: 25 Pages: 2667-2672 Published: DEC 22 2005
Times Cited: 187
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A ( H5N1) virus infection include additional antiviral agents.
编辑: yang
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