志愿者感言 详细 >>
志愿者霍卫平：我们候鸟式的救援工作，比起大量贫困农民大病当小病，小病当无病的“怪圈”，显得如此单薄而无力！医疗救助工作任重而道远……
志愿者武宇辉：博爱志愿者们，希望我们能在下次活动中再见！愿博爱撒到每一个地方。
志愿者杨颜菲：感觉完成了任务，心里安心，这些事情对于我来说算是一种提高，还有一种义务在心里。
志愿者曹飞：希望我们能带动更多的人、更多的像上汽通用五菱这样的爱心企业加入到我们的爱心行动之中，壮大博爱活动，共同致力于促进落后地区医疗卫生事业的发展！
志愿者何仁亮：或许我们只能为他们做出一点点，但我想只要我们每个人一点点，爱就会如同汉江一样汇聚成爱的海洋！
Sir Martin J. Evans的研究领域
Sir Martin Evans is former Director of the School of Biosciences and Professor of Mammalian Genetics of Cardiff University.
After graduating from Cambridge in 1963 I decided on a career studying the genetic control of vertebrate development and undertook research for my PhD at University College London in the department of Anatomy and Embryology. During this early research on changes of messenger RNA profile during neural induction in Xenopus I was using pioneering techniques of agarose gel electrophoresis and metabolic double labelling. These experiences led to a realisation of the need for a tractable experimental system to study development in isolation from the whole embryo and with the possibilities of genetic manipulation and I therefore chose to explore the use of cultures of mouse teratocarcinoma stem cells in tissue culture systems. I was the first to maintain these cells in tissue culture under conditions where their ability to differentiate was retained indefinitely. Studies from my laboratory showed extensive differentiation of these cells in culture and the means whereby this happened was shown to be that corresponding to organisation of a normal mouse embryo. Moreover these cells would participate extensively in normal development in combination with a normal embryo and give rise to adult mice.
These studies showed the close relationship between these "EC" cells and normal mouse embryos but it was not until 1981 after my return to Cambridge that together with Matt Kaufman he was able to isolate similar cells from normal mouse embryos. Subsequently we rapidly demonstrated, together with my student and post-doc Liz Robertson and student Allan Bradley, that these cells which became known as "Embryonic Stem Cells" (ES cells) were able to be used to fully regenerate fertile breeding mice from the tissue culture cells and that these could therefore carry mutations introduced and selected or screened for in culture. This is now the basis of all the mouse knockout and targetted genetic manipulation.
Since pioneering these fundamental developments which created new routes to experimental mammalian genetics and hence functional genomics, I have been exploiting them using gene knockout and gene trap methods both for novel discovery and to create animal modes of human disease. From my laboratory came the first demonstration of gene therapy to cure the deficit in Cystic Fibrosis in the whole animal and recently, from a mutated mouse model, insights into the breast cancer gene BRCA2 function.
Microarray transcriptomics has allowed new insights into the phenotypec changes resulting from gne knockout and we have been exploiting this mainly in the sparc mouse model. I am also becoming increasingly interested in the relationship between mouse ES cells and the normal embryo and microarray analysis of amplified RNA tartget allows global transcriptomic sensitive comparisons to be made.
I have published 149 scientific papers, including the following. I am a Fellow of the Royal Society and a founder Fellow of the Academy of Medical Sciences, Doctor of Philosophy and Doctor of Science. Honorary Doctorates from Mt Sinai School of Medicine and from Bath University.
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