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专家风采
欧阳应斌（Marvin Ouyang）博士
Indiana大学博士后、Cyagen Biosciences技术副总裁
2012,01-现在
任职于赛业生物科技有限公司，担任高级科学家。统领赛业（美国）和赛业（广州）分子生物学和模式动物技术团队，打造国际最前沿的技术体系和最高效的模式动物技术平台。
2004,12-2011,12
任职于美国Taconic生物科技公司，担任分子生物学部主管。率领十余位科学家成功开发建成四百余种转基因小鼠及大鼠实验动物及疾病模型。
2002,05-2004,11
任职于美国Thios生物制药公司，担任生物部科学家。在哺乳动物细胞及昆虫细胞高效表达了六种硫酸转移酶及重组抗体，有力推动了硫酸转移酶小分子抑制剂及重组抗体制药的研发。
1997,08-2002，05
任职于美国Oklahoma医学研究基金会，担任高级科学家。成功发现，纯化并克隆了两种硫蛋白转移酶，成功建成基因敲出小鼠模型。研究了在生理，病理过程中的功能。
1995,07-1997,08
美国Indianan大学医学院，博士后。从事信号转导研究。
1993,08-1995,06
任职于北京军事医学科学院生物工程研究所，担任助理研究员。在中国仓鼠卵细胞中高效表达了组织型纤溶酶元激活剂(t-PA)，建成高效表达t-PA的工程细胞株。
代表性论文
1. Verkoczy L, Chen Y, Bouton-Verville H, Zhang J, Diaz M, Hutchinson J, Scearce RM, Ouyang YB, Alam M, Holl M, Hwang KK, Kelsoe G, and Haynes BF: Rescue of HIV-1 broad neutralizing antibody-expressing immature B cells from clonal deletion in 2F5 VH/VL knock-in mice reveals additional tolerance controls. J. Immunol. 187:3785-97, 2011
2. Verkoczy L, Diaz M, Holl TM, Ouyang YB, Bouton-Verville H, Alam SM, Liao HX, Kelsoe G, Haynes BF: Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci U S A. 107:181-6, 2010
3. Borghei A, Ouyang YB (Co-first author), Westmuckett AD, Marcello MR, Landel CP, and Moore KL: Target disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility. J. Biol. Chem. 281: 9423- 9431, 2006
4. Ouyang YB, Crawley JT, Aston CE, and Moore KL: Reduced body weight and increased post-implantation fetal death in tyrosylprotein sulfotransferase-1 deficient mice. J. Biol. Chem. 277:23781-23787, 2002
5. Shen R, Ouyang YB, Qu C, Kaplan MH, and Feng GS: Grap negatively regulates T- cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol. 22:10:3230-3236, 2002
6. Kehoe JW, Maly DJ, Verdugo DE, Armstrong JI, Cook BN, Ouyang YB, Moore KL, Ellman JA, and Bertozzi CR: Tyrosyprotein sulfotransferase inhibitors generated by combinatorial targeted-guided ligand assembly. Bioorg Med Chem Lett. 12:329-332, 2002
7. Leppanen A, Mehta P, Ouyang YB, Ju T, Helin J, Moore KL, van Die I, Canfield WM, McEver RP, and Cummings RD: A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin. J. Biol. Chem. 274:24838-48, 1999
8. Ouyang YB, Lane WS, and Moore KL: Tyrosylprotein sulfotransferase: Purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common post-translational modification of eukaryotic proteins. Proc. Natl. Acad. Sci. USA. 95: 2896-2901, 1998
9. Ouyang YB and Moore KL: Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. J. Biol. Chem. 273: 24770-24774, 1998
10. Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, and Ni J: Grap is a novel SH3-SH2-SH3 adapter protein that couples tyrosine kinases to the Ras pathway. J. Biol. Chem. 271:12129-12132, 1996
11. Ouyang YB, Huang PT, and Huang CF: Inhibitory effect of 3'-untranslated region (3'-UTR) of human tissue-plasminogen activator (ht-PA) mRNA on its expression. Science in China (Seri B) 38:1253-1260, 1995
12. Ouyang YB, Huang PT, and Huang CF: Influence of 5'-untranslatedregion (UTR) sequence on the regulation of human tissue-plasminogen activator (t-PA) mRNA expression. Chinese Science Bulletin 40:1378-1383, 1995
13. Ouyang YB, Huang PT, Xu XY, Chen L, and Huang CF: The regulation and high level expression of human tissue-type plasminogen activator(t-PA): ---II: Efficient and stable expression of human tissue-plasminogen activator (t-PA) cDNA in Chinese hamster ovary (CHO) cells. Science in China (Seri C) 26:92-96, 1996
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