东京大学医学院Haruhiko Bito副教授
Haruhiko Bito, MD, PhD
Research and Professional Experience:
1990 MD, Univeristy of Tokyo Faculty of Medicine
1993 PhD, University of Tokyo Graduate School of Medicine
1993-1997 Postdoctoral scholar, Stanford University School of Medicine
(Advisor: Richard W. Tsien, D. Phil.)
1997-2002 Assistant Professor of Pharmacology,
Kyoto University Graduate School of Medicine
2003-Pres Associate Professor and Head, Department of Neurochemistry
University of Tokyo Graduate School of Medicine
Awards:
Selected Publications:
2011
Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RG. Schema-dependent gene activation and memory encoding in neocortex. Science. 2011 Aug 12;333(6044):891-5. Epub 2011 Jul 7.
2010
Takemoto-Kimura, S., Suzuki, K., Kamijo, S., Ageta-Ishihara, N., Fujii, H., Okuno, H., & Bito, H.. Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits. Eur. J. Neurosci. 32, 224-230, (2010).
Bito, H. The chemical biology of synapses and neuronal circuits. Nature Chem. Biol. 6, 560-563, (2010).
Kim, T.K., Hemberg, M., Gray, J.M., Costa, A.M., Bear, D.M., Wu, J., Harmin, D.A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., Markenscoff-Papadimitriou, E., Kuhl, D., Bito, H., Worley, P.F., Kreiman, G., Greenberg, M.E. Widespread transcription at neuronal activity-regulated enhancers. Nature, 465, 182-187, (2010).
Redondo, R.L., Okuno, H., Spooner, P.A., Frenguelli, B.G., Bito, H. & Morris, R.G.M. Synaptic tagging and capture: differential role of distinct calcium-calmodulin kinases in protein synthesis-dependent long-term potentiation. J. Neurosci. 30, 4981-4989, (2010).
2009
Ageta-Ishihara, N., Takemoto-Kimura, S., Nonaka, M., Adachi-Morishima, A., Kamijo, S., Suzuki, S., Fujii, H., Mano, M., Blaeser, F., Chatila, T.A., Mizuno, H., Hirano, T., Tagawa, Y., Okuno, H. & Bito, H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J. Neurosci. 29, 13720-13729, (2009).
Kawashima, T., Okuno, H., Nonaka, M., Adachi-Morishima, A., Kyo, N., Okamura, M., Takemoto-Kimura, S., Worley, P., Bito, H. A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons, Proc. Natl. Acad. Sci. USA 106, 316-321, (2009).
Nonaka M. A Janus-like role of CREB protein: enhancement of synaptic property in mature neurons and suppression of synaptogenesis and reduced network synchrony in early development. J Neurosci. 29, 6389-6391, (2009).
2008
Bito, H., Takemoto-Kimura, S., Okuno, H. Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? in “Molecular Pain” (M. Zhuo ed. Springer), (2008).
2007
Fuse, T., Ohmae, S., Takemoto-Kimura, S., Bito, H. DCLK1. AfCS/Nature Molecule Pages, doi:10.1038/mp.a003011.01, (2007).
Takemoto-Kimura, S., Ageta-Ishihara, N., Nonaka, M., Adachi-Morishima, A., Mano, T., Okamura, M., Fujii, H., Fuse, T., Hoshino, M., Suzuki, S., Kojima, M., Mishina, M., Okuno, H., Bito, H. Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron 54: 755-770, (2007).
Kiyonaka, S., Wakamori, M., Miki, T., Uriu, Y., Nonaka, M., Bito, H., Beedle, A.M., Mori, E., Hara, Y., De Waard, M., Kanagawa, M., Itakura, M., Takahashi, M., Campbell, K.P., Mori, Y. The active zone protein RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nature Neurosci. 10: 691-701, (2007).
2006
Chowdhury, S., Shepherd, JD., Okuno, H., Lyford, G., Petralia, RS., Plath, N., Kuhl, D., Huganir, RL. & Worley, PF. Arc interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52: 445-59, (2006).
Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T.A., Bito, H., Takayanagi, H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nature Med. 12: 1410-1416, (2006).
Yamana, N., Arakawa, Y., Nishino, T., Kurokawa, K., Tanji, M., Itoh, RE., Monypenny, J., Ishizaki, T., Bito, H., Nozaki, K., Hashimoto, K., Matsuda, M., Narumiya, S. Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing APC and c-Src. Mol. Cell Biol., 26: 6844-6858, (2006).
Kuriu, T., Inoue, A., Bito, H., Sobue, K., Okabe, S. Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms. J. Neurosci. 26: 7693-7706, (2006).
Ohmae, S., Takemoto-Kimura, S., Okamura, M., Adachi-Morishima, A., Nonaka, M., Fuse, T., Kida, S., Tanji, M., Furuyashiki, T., Arakawa, Y., Narumiya, S., Okuno, H., Bito H. Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKIV. J. Biol. Chem. 281: 20427-20439, (2006).
Uemura, K., Kihara, T., Kuzuya, A., Okawa, K., Nishimoto, T., Bito, H., Ninomiya, H., Sugimoto, H., Kinoshita, A., Shimohama, S. Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochem Biophys Res Commun. 345: 951-958, (2006).
Nonaka, M., Doi, T., Fujiyoshi, Y., Takemoto-Kimura, S., Bito, H. Essential contribution of the ligand-binding bB-bC loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding and localization of PSD-95, J. Neurosci. 26: 763-774, (2006).
Okuno, H. and Bito H. CREB1. AfCS/Nature Molecule Pages, doi:10.1038/ mp.a000690.01 , (2006).
2005
Iki, J., Inoue, A., Bito, H., Okabe, S. Bidirectional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity. Eur. J. Neurosci. 22, 2985-2994, (2005).
Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S. Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proc. Natl. Acad. Sci. USA 102, 16066-16071, (2005).
Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y.V., Fukuda, A., Fuse, T., Matsuo, N., Sone, M., Watanabe, M., Bito, H., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., and Nabeshima, Y. Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron 47, 201-213, (2005).
2004
Nemoto, T.., Kojima, T.., Oshima, A., Bito, H., Kasai, H. Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini. J. Biol. Chem. 279, 37544-37550, (2004).
Suga, H., Takeda, S., Haga, T., Okamura, M., Takao, K., and Takemoto, K. Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Gα16 fusion proteins. J. Biochem. 135, 605-613 , (2004).
Takeda, S., Okada, T., Okamura, M., Haga, T., Isoyama-Tanaka, J., Kuwahara, H., and Minamino, N. The receptor-Gα fusion protein as a tool for ligand screening: A model study using a nociceptin receptor-Gαi2 fusion protein. J. Biochem. 135, 597-604 , (2004).
Zhang, Q., Okamura, M., Guo, Z.-D., Niwa, S., and Haga, T. Effects of partial agonists and Mg2+ ions on the interactions of M2 muscarinic acetylcholine receptor and G protein Gαi1 subunit in the M2-Gαi1 fusion protein. J. Biochem. 135, 589-596 , (2004).
2003
Bito H, Takemoto-Kimura S. Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival. Cell Calcium, 34: 425-430, (2003).
Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Furuyashiki T, Arakawa Y, Narumiya S, Bito H. Molecular cloning and characteriation of CLICK-III/CaMKIg, a novel membrane anchored neuronal CaMK. J. Biol. Chem., 278: 18597-18605, (2003).
Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N, Narumiya S. Control of axon elongation via an SDF-1a / Rho / mDia pathway in cultured cerebellar granule neurons. J.Cell Biol., 161: 381-391, (2003).
Matsuoka Y, Furuyashiki T, Bito H, Ushikubi F, Tanaka Y, Kobayashi T, Muro S, Satoh N, Kayahara T, Higashi M, Mizoguchi A, Shichi H, Fukuda Y, Nakao K, Narumiya S. Impaired adrenocorticotropic hormone response to bacterial bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proc. Nat. Acad. Sci. USA, 100: 4132-4137, (2003).
Okuda T, Haga T. High-affinity choline transporter. Neurochem Res. 28: 483-488, (2003).
Bito H. Dynamic control of neuronal morphogenesis by rho signaling.. J Biochem. 134: 315-319, (2003).
Fujii T, Okuda T, Haga T, Kawashima K. Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line. Life Sci. 72: 2131-2134, (2003).
2002
Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H, Narumiya S. Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc. Natl. Acad. Sci. USA 99: 14458-14463, (2002).
Okuda T, Okamura M, Kaitsuka C, Haga T, Gurwitz D. Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. J Biol Chem. 277: 45315-45322, (2002).
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