中科院神经所熊志奇教授
Zhi-Qi Xiong, Ph.D.
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PUBLICATIONS
1. Tan G-H, Liu Y-Y, Hu X-L , Yin DM, Mei L and Xiong Z-Q. (2011) Neuregulin1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. In revision
2. Chen WJ, Lin Y, Xiong Z-Q, Tan GH, Guo SL, Wei W, Ni W, , Xu J, He J, Chen YF, Lin Y, Murong SX, Wang N, Wu Z-Y. (2011) Exome sequencing revealed a complete co-segregation of truncated mutations in the PRRT2 gene with paroxysmal kinesigenic dyskinesia. In revision
3. Hu XL, Chen XW, Fei J and Xiong Z-Q. (2011) NRSF is not required for the anti-epileptic effect of ketogenic diet. Epilepsia. In press
4. Guo SL, Li S, Tan GH, Cheng XW, Jia YF, Xiong H, Zhang C, and Xiong Z-Q. (2011) SNK is a positive regulator of dendritogenesis and is necessary for BDNF-induced dendrite growth. Cell Research. In press.
5. Hu XL, Chen XW, Cai L, Tan GH, Xu L, Feng XY, Lu LT, Xiong H, Fei J and Xiong Z-Q. (2011) Conditional deletion of NRSF in forebrain accelerated epileptogenesis in the kindling model. Cerebral Cortex. In Press.
6. Chen XW, Li Y, Huang Y, Feng XY, Feng G, and Xiong Z-Q. (2011) Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone. Cell Research. 21: 338-349.
7. Chen Q, Zhu YC, Yu J, Miao S, Zheng J, Xu L, Li D, Zhang C, Tao J, and Xiong Z-Q. (2010) CDKL5, A protein associated with Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. J Neurosci. 30:12777-12786.
8. Qiu LF, Lu T-J, Hu X-L, Yi YH, Liao WP, and Xiong Z-Q. (2009) Limbic epileptogenesis in a mouse model of fragile X syndrome. Cerebral Cortex. 19: 1504-1514.
9. Li S, Zhang C, Takemori H, Zhou Y, and Xiong Z-Q. (2009) TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J. Neurosci. 29: 2334-2343.
10. Chen M, Chen Q, Cheng X-W, Lu T-J, Liu H-X, Jia J-M, Zhang C, Xu L, and Xiong Z-Q (2009) Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus. J. Neurochem. 111: 1094-1103.
11. Zhou Y, Lu T-J and Xiong Z-Q. (2009) NGF-dependent retrograde signaling: survival versus death. Cell Research. 19: 525-526. (Preview)
12. Chen M, Lu T-J, Chen XJ, Zhou Y, Chen Q, Feng XY, Xu L, Duan WH and Xiong Z-Q. (2008) Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke. 39: 3042-3048.
13. Jia J-M, Chen Q, Zhou Y, Mao S, Zheng J, Zhang C, and Xiong Z-Q. (2008) BDNF-TrkB signaling contributes to proteasome-dependent homeostatic regulation of synaptic proteins. J. Biol. Chem. 283: 21242-21250
14. Zheng J, Shen W, Lu T-J, Zhou Y, Chen Q, Wang Z, Xiang T, Zhu Y-C, Zhang C, Duan S, and Xiong Z-Q. (2008) Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth. J. Biol. Chem. 283:13280-13288.
15. Qiu HY, Guo C, Cheng XW, Huang Y, Xiong Z-Q, and Ding YQ. (2008) Pitx3-CreER mice showing restricted Cre expression in developing ocular lens and skeletal muscles. Genesis. 46:324-328.
16. Huang YZ, Pan E, Xiong Z-Q, and McNamara JO. (2008) Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 synapses. Neuron. 57: 546-558.
17. Zhang XB, Jiang P, Gong N, Hu XL, Fei D, Xiong ZQ, Xu L, Xu TL (2008). A-type GABA receptor as a central target of TRPM8 agonist menthol. PLoS ONE, 3: e3386.
18. Zhang X-H, Liu F, Qian C, Zhang C-L, Zhuo M, Xiong Z-Q, and Li B-M. (2008) Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. Neuropharmacology. 55: 238-246
19. Wu H, Zhou Y, and Xiong Z-Q. (2007) Transducer of regulated CREB and late phase long-term synaptic potentiation. FEBS J. 274: 3218-3223. (MiniReview)
20. Chen Q, He S, Hu X-L, Yu J, Zhou Y, Zheng J, Zhang S, Zhang C, Duan W-H, and Xiong Z-Q. (2007) Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. J. Neurosci. 27：542-552.
21. Wang CL, Zhang L, Zhou Y, Zhou J, Yang XJ, Duan SM, Xiong Z-Q, Ding YQ. (2007) Activity-dependent development of callosal projections in the somatosensory cortex. J. Neurosci. 27:11334-11342.
22. Zhou Y, Wu H, Li S, Chen Q, Cheng X-W, Zheng J, Takemori H, and Xiong Z-Q. (2006). Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS ONE. 1:e16.
23. Wang LC, Xiong W, Zheng J, Zhou Y, Zheng H, Zhang C, Zheng LH, Zhu XL, Xiong Z-Q, Wang LY, Cheng HP, and Zhou Z. (2006). The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron. Biophys J. 90:3590-3598.
24. Xiong Z-Q, Qian W, Suzuki K, and McNamara JO. (2003). Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. J. Neurosci. 23:955-960.
25. Xiong Z-Q and McNamara JO. (2002). Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. Neuron 36: 363-374.
26. Xiong Z-Q and McNamara JO. (2002). Fas(t) balls and Lou Gehrig disease: a clue to selective vulnerability of motor neurons? Neuron 35: 1011-1013. (preview)
27. Xiong Z-Q and Stringer JL. (2001). Prolonged bursts occur in normal calcium levels in hippocampal slices after raising excitability and blocking synaptic transmission. J. Neurophysiol. 86: 2625-2628.
28. Xiong Z-Q and Stringer JL. (2001). Effects of postsynaptic GABAB receptor activation on epileptiform activity in hippocampal slices. Neuropharmacology 40: 131-138.
29. Xiong Z-Q, Saggau P, and Stringer JL. (2000). Activity-dependent intracellular acidification correlates with the duration of seizure activity. J. Neurosci. 20: 1290-1296.
30. Xiong Z-Q and Stringer JL. (2000). Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression. J. Neurophysiol. 83: 3519-3524.
31. Schweitzer JS, Wang H, Xiong Z-Q, and Stringer JL. (2000). pH sensitivity of non-synaptic field bursts in the dentate gyrus. J. Neurophysiol. 84: 927-933.
32. Xiong Z-Q and Stringer JL. (2000). Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus. J. Neurophysiol. 83: 1443-1451.
33. Xiong Z-Q and Stringer JL. (2000). Regulation of extracellular pH in the developing hippocampus. Dev. Brain Res. 122: 113-117.
34. Xiong Z-Q and Stringer JL. (1999). Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo. Eur. J. Neurosci. 11: 1677-1684.
35. Xiong Z-Q and Stringer JL. (1999). Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus. J. Neurophysiol. 82: 3339-3346.
36. Xiong Z-Q, Cheng DH, and Tang XC. (1998). Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Acta Pharmacologica Sinica 19: 128-132.
37. Xiong Z-Q and Stringer JL. (1997). Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. Epilepsy Res. 27: 187-194.
38. Xiong Z-Q, Han YF, and Tang XC. (1995). Huperzine A ameliorates the spatial working memory impairments induced by AF64A. NeuroReport 6: 2221-2224.
39. Xiong Z-Q and Tang XC. (1995). Effect of huperzine A, a novel acetyl-cholinesterase inhibitor, on radial maze performance in rats. Pharmacol. Biochem. Behav. 51: 415-419.
40. Xiong Z-Q and Tang XC. (1995). Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment. Acta Pharmacologica Sinica 16: 21-25.
41. Xiong Z-Q and Tang XC. (1995). Effect of n-nitro-l -arginine on eight-arm maze performance in rats. Acta Pharmacologica Sinica 16: 301-304.
42. Tang XC, Xiong Z-Q, Qian BC, Zhou ZF. (1994). Cognition improvement by oral huperzine A: a novel acetylcholinesterase inhibitor. In Giacobini E and Becker R Eds. Alzheimer Therapy: Therapeutic Strategies. Birkhauser, Boston. 113-119 (review)
MEMBERSHIP
1995-present Member, Society for Neuroscience
2005-Present Member, Chinese Society for Neuroscience
2005-Present Member, Shanghai Society for Neuroscience
2007-present Member, Chinese Society for Cell Biology
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