中科院神经所王以政教授
Laboratory of Neural Signal Transduction
Yizheng Wang
Curriculum Vitae
Education: Medical degree, China Medical College (1982)
Ph.D., University of Laval. Canada (1991)
Positions:
2001- Institute of Neuroscience, Chinese Academy of Science, Shanghai, China.
Publications:
1．Wang, YZ., Simonson, MS., Pouyssegur, J. and Dunn, MJ. (1992) Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. Biochem. J. 287, 589-594
2. Simonson, MS., Wang, YZ., Jones, JM. and Dunn, MJ. (1992) Protein kinase C regulates activation of mitogen-activated protein kinase and induction of proto-oncogene c-fos by endothelin-1. J. Cardiovas. Pharma. 20, S29-S32
3. Wang, YZ., Pouyssegur, J. and Dunn, MJ. (1993) Endothelin stimulates mitogen-activated protein kinase p42 activity through the phosphorylation of the kinase in rat mesangial cells. J. Cadiovas. Pharma. 22, S164-S167
4. Schramek, H., Wang, YZ., Konieczkowski, M., Rose, PM., Sedor, JR. and Dunn, MJ. (1994) Endothelin-1 stimulates cytosolic phospholipase A2 in Chinese hamster ovary cells stably expressing the human ETA or ETB receptor subtype. Biochem. Biophys. Res. Commun. 199, 992-997
5. Wang, YZ., Pouyssegur, J. and Dunn, MJ. (1994) Endothelin stimulates mitogen-activated protein kinase activity in mesangial cells through ETA. JASN. 5, 1074-1080.
6. Wang, YZ., Rose, PM., Webb, M. and Dunn, MJ. (1994) Endothelins stimulate the mitogen-activated protein kinase cascade through either ETA or ETB. Amer. J. Physiol. 267 (Cell Physiol. 36), C1130-C1135.
7. Schramek, H., Wang, YZ., Konieczkowski, M., Simoson, M. and Dunn, MJ. (1994) Endothelin-1 stimulates cytosolic phospholipase A2 activity and gene expression in rat glomerular mesangial cells. Kidney Inter. 46, 1644-1652
8. Wang, YZ. and Durkin, J. (1995) AMPA, but not NMDA, activates MAP kinase through G-protein bg subunits in rat cortical neurons. J. Biol. Chem. 270, 22783-22787.
9. Wang, YZ., Schramek, H. and Dunn, MJ. (1996) Cytosolic and nuclear mitogen-activated protein kinases are regulated by two distinct mechanisms. Exp. Cell. Res. 225, 382-388
10. Coroneos, E., Wang, YZ., Panuska, JR., Templeton, DJ. and Kester, M. (1996) Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase (ERK) and stress-activated protein kinase (SPAK) cascades. Biochem. J. 316, 13-17.
11. Testolin, L., Carson, C., Wang, YZ., Walker, PR. Armato, U and Sicroska, M. (1997) Jun and JNK kinase are activated in thymocytes in response to VM26 and radiation but not glucocorticoids. Exp. Cell Res. 230, 220-232.
12. Wang, YZ., Samll, D., Stanimirovic, D., Morley, P. and Durkin, J. (1997) AMPA-mediated regulation of a Gi-protein in cortical neurons. Nature 389, 502-504.
13. Mandal, A., Wang, YZ., Ernsberger, P. and Kester, M. (1997) Il-1-induced ether-linked diglycerides inhibit calcium-insensitive PKC isotypes: implications for growth senescence. J. Biol. Chem. 272, 20306-20311.
14. Tauskela, JS., Chavravarty, B., Murray, C., Wang, YZ., Coma, T., Hogen, MJ., Hakim, AM. and Morley, P. (1999) Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart. Brain Res. 827, 143-151
15. Bourbon, NA., Berkey, D., Wang, YZ. and Kester, M. (2001) Ceramide differentially regulates PKC/MAPK interaction: Implications for growth arrest. Amer. J. Physiol. (Cell Physiol.) 280, C1403-C1411
16. Wang, YZ., Guan, J., Wang, HY., Wang, Y., Leeper, D. and Iliakis, G., et al (2001) Regulation of DNA replication after heat shock by RPA-nucleolin interactions. J. Biol. Chem. 276, 20579-20588
17. Regan, RF, Wang YZ and Guo,YP. (2002) Activation of extracellular regulated kinases potentiates heme-mediated oxidative injury to astrocytes. J. Neurochem. 79, 545-555
18．Ye, YZ., Xi, W., Peng, YQ., Wang, YZ., and Guo, AK. (2004) Long-term but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. Eur. J. Neurosci. 20, 1001-1007.
19．Li. Y, Jia, YC, Cui, K, Li, N, Zheng, ZY, Wang, YZ, Yuan, XB (2005) Essential role of TRPC channels in the guidance of nerve growth cone by BDNF. Nature. 434, 894-898
20. Tao, YM., Zeng, R., Shen, B., Jia, JM., and Wang, YZ. (2005) Neuronal transmission stimulates the phosphorylation of Kv1.4 channel at Ser229 through protein kinase A. J. Neurochem. 94，1512-1522.
21. Tao, YM., Yan, D., Yang, QY. and Wang, YZ. (2006) Low K+ promotes NF-kB DNA binding in neuronal apoptosis induced by K+ loss. Mol. Cell Biol. 26(3), 1038-1050
22. Yan, D., Gou, L. and Wang, YZ. (2006) Requirement of dendritic Akt degradation by the ubiquitin proteasome system for neuronal polarity. J. Cell Biol. 174 415-424
23．Yang, QY., Yan, D. and Wang, YZ. (2006) The K+ Regulates DNA Binding of transcription factors to control gene expression related to neuronal apoptosis. NeuroReport. 17(11):1199-204
24. Huang, CX., Jia, YC., Yang, SL., Chen, B., Sun, HW., Shen, F. and Wang, YZ. (2007) Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313(2):254-263.
25. Guo, L. and Wang, YZ. (2007) Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2. Neuroscience 145:100-109
26. Wang, ZH., Shen, B., Yao, HL., Jia, YC., Jin, R., Feng, YJ. and Wang, YZ. (2007) Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene 26, 5107-5114
27. Jia, YC., Zhuo, J., Tai, YL. and Wang YZ. (2007) TRPC channels promote cerebellar granule neuron survival. Nature Neuroscience 10，559-567.
28．Wang, WY., Yang, Y., Ying CY., Li, WM., Ruan, HL., Zhu, XN., You, Y., Han, YF., Chen, RZ., Wang YZ., Li, MT. (2007) Inhibition of glycogen synthase kinase-3b protects dopaminergic neurons from MPTP toxicity. Neurophanrmacology (52) 1678-1684
29. Shen, B. Zhou, KC., Yang, SL., Xu, TL. and Wang, YZ. (2008) The Kv4.2 Mediates Excitatory Activity-Dependent Regulation of Neuronal Excitability in Rat Cortical Neurons. J. Neurochem. 105, 773-783
30. Zhou, J., Du, WL., Zhou., KC., Tai, YL., Jia, YC., and Wang YZ. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nature Neuroscience. 11，741-743.
31. Tai, YL., Feng, SJ., Du, WL., Zhang, XX., and Wang YZ. (2008) The TRPC6 promotes dendritic growth via the CaMIV-CREB pathway. J. Cell Sci. 121，2301-2307.
32. Huang, C., Yang, S., Ge, R., Sun, H., Shen, F., and Wang, YZ. (2008) ZNF23 induces apoptosis in human ovarian cancer cells. Cancer Lett. 266，135-143.
33. Yao, YY., Ding, X., Jia, JC., Huang, CX., Wang, YZ., and Xu, YH. (2008) Anti-tumor effect of b-elemene in glioblastoma cells depends on p38MAK activation. Cancer Lett. 264，127-134.
34．Yang，SL., Cao, Q., Zhou, KC., Feng, YJ and Wang, YZ. (2009) Transient Receptor Potential Channel C3 contributes to the progression of human ovarian cancer. Oncogene 28, 1320-1328
35. Yao, HL., Zhou, KC., Yan, D., Li, MT. and Wang, YZ. (2009) The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. J. Neurochem.108, 909-919
36．Ge, RL., Tai, YL., Sun, YY., Zhou, KC., Yang, SL., Cheng, TL., Zou, QF., Shen, F. and Wang, YZ. (2009) Critical role of TRPC6 channels in VEGF-mediated angiogenesis. Cancer Lett. 283, 43-51
37．Cai, R., Ding, X., Zhou, KC., Shi,Y., Ge, RL., Ren, G., Jin, YN. and Wang, YZ. (2009) Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Intl. J. Cancer 125, 2281-2287.
38. Yuan, ZM., Gong, SF., Luo, JY., Zheng, ZH., Song, B., Ma, SS., Guo, JL., Hu, C., Thiel, G.., Vinson, C., Hu, CD., Wang, YZ. and Li, MT. (2009) Opposing Roles for ATF2 and c-Fos in c-Jun-Mediated Neuronal Apoptosis. Mol. Cell. Biol. 29, 2431-2442_
39．Shi, Y., Ding, X., He, ZH., Zhou, KC., Wang, Q. and Wang, YZ. (2009) Critical role of TRPC6 in G2 phase transition and development of human esophageal cancer. Gut 58，1443-1450.
40．Ding, X., He, ZH., Zhou, KC., Cheng, J., Yao, HL., Cai, R., Jin, YN. and Wang, YZ. (2010) Essential role of TRPC6 channels in G2 phase progression and glioma development. J. Ntal. Cancer Inst. 102 (14):1052-1068.
41. Du, WL., Huang, JB., Yao, HL., Zhou, KC., Duan, B. and Wang, YZ. (2010) Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. J. Clin. Invest. 120(10):3480-3492.
42. Hou, Y., Zou, QF., Shen, F., and Wang, YZ. (2011) Critical role of CD133+CD44+/high tumor cells in hematogenous metastasis of liver cancers. Cell Res. In press
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