默克密理博干细胞/细胞生物学部Vi Chu博士
Vi Chu, Ph.D.
R&D Manager, Stem Cells & Cell Biology
EMD-Millipore
Vi Chu obtained her PhD in RNA biochemistry in 2000 at Columbia University in the Howard Hughes laboratory of Dr. Anna Pyle. From 2000-2004, Dr. Chu was a postdoctoral fellow at the Salk Institute in the laboratory of Dr. Fred Gage. At the Salk, Dr. Chu focused on establishing conditions to direct the differentiation of neural stem cells to specific CNS lineages for gene expression profiling studies. In the process, she uncovered the presence of L1 retrotransposons in neural stem cells. Dr. Chu joined Millipore in 2004 and became R&D manager in 2007. At EMD-Millipore, (a division of Merck KGaA), Dr. Chu’s team is focused on developing media reagents, characterization tools and kits to facilitate research in stem cell biology, reprogramming and cellular biology.
Publications:
1) Muotri A.R., Chu, V. T., Marchetto, M. C., Deng, W., Moran, J. V., and Gage, F. H. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. (2005) Nature, 435 (7044): 903-910.
Note: Co-first author.
2) Chu, V. T., and Gage, F. H. Chipping away at stem cells. (2001) Proc. Natl. Acad. Sci. U.S.A., 98 (14): 7652-7653.
3) Chu, V. T., Adamidi, C., Liu, Q., Perlman, P. S., and Pyle, A. M. Control of branch-site choice by a group II intron. (2001) EMBO J., 20 (23): 6866-6876.
4) Pyle, A. M., Chu, V. T., Jankowsky, E., and Boudvillain, M. Using DNAzymes to cut, process and map RNA molecules for structural studies or modifications. (2000) Methods in Enzymology, 317: 140-146.
5) Chu, V. T., Liu, Q., Podar, M., Perlman, P. S., and Pyle, A. M. More than one way to splice an RNA: Branching without a bulge and splicing without branching in group II introns. (1998) RNA, 4: 1186-1202.
6) Podar, M., Chu, V. T., Pyle, A. M., and Perlman, P. S. Group II intron splicing in vivo by first-step hydrolysis. (1998) Nature, 391: 915-918.
7) Josiah, S. M., Cyr, C. R., Chu, V., Grumet, M., Gardner, J. P., and Kris, R. M. Regions of the human neurokinin A receptor involved in the generalization of second messengers and in receptor desensitization. (1994) Biochem Biophys Res Commun, 199 (2): 626-632.
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