香港大学Dr. Ma Kwai Yee教授
Dr MA Kwai Yee, Stephanie | sma@pathology.hku.hk / stefma@hkucc.hku.hk
Research Assistant Professor / Honorary Assistant Professor
BSc Canada; MSc Canada; PhD HK
Cancer stem cells / Molecular pathogenesis of human cancers
Research Interest
My current research work focuses on:
Identification and characterization of cancer stem cells / tumor-initiating cells in the liver
Role of miRNAs in the development and progression of liver and prostate cancers
Identification of novel oncogenes and tumor suppressor genes involved in liver, prostate and esophageal cancers
Postgraduate (MPhil / PhD) positions available. Interested applicants can send an email to sma@pathology.hku.hk to enquire for more details.
Awards and Honors
Faculty Outstanding Research Output Award, The University of Hong Kong (2011)
Hong Kong Young Scientist Award (Life Sciences), Hong Kong Institution of Science (2008)
International Society for Stem Cell Research (ISSCR) Travel Award (2007)
Li Ka Shing Prize for the Best Ph.D. Thesis, The University of Hong Kong (2006-2007)
Outstanding Young Scientist Travel Award, National Institute of Health (2001)
Research Grants
RGC General Research Fund
The role of interleukin-8 (IL-8) and efficacy of IL-8 targeted therapy in CD133+ cancer stem cells-driven hepatocellular carcinoma (2011) (Co-Investigator)
Recent Publication Lists
Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated Nanog regulation. Cell Stem Cell 2011; 9: 50-63.
Luk SU, Lee TK, Liu J, Lee DT, Chiu YT, Ma S, Ng IO, Wong YC, Chan FL, Ling MT. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One 2011; 6: e19804.
Tong CM#, Ma S#, Guan XY. Biology of hepatic cancer stem cells. J Gastroenterol Hepatol 2011; 26: 1229-37. (invited review) (#co-first authors)
Ma S^, Guan XY. miRegulators in cancer stem cells of solid tumors. Cell Cycle 2011; 10: 571-2. (invited commentary article) (^co-corresponding author)
Ma S^, Chan YP, Kwan PS, Lee TK, Yan M, Tang KH, Ling MT, Vielkind J, Guan XY, Chan KW^. microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2. Cancer Res 2011; 71: 583-92. (^co-corresponding authors)
Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh PY. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest 2011; 121: 880-92.
Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor initiating cells through PTEN modulation. Hepatology 2011; 53: 160-70.
Tang KH#, Ma S#, Guan XY. Liver tumor-initiating cells / cancer stem cells: past studies, current status and future perspectives. In: Advances in Cancer Stem Cell Biology (Ed. R Scatena). Springer Publishing, 2011, ISBN 978-1-4614-0808-6. (#co-first authors)
Luk SU, Yap WN, Chiu YT, Lee DT, Ma S, Lee TK, Vasireddy RS, Wong YC, Ching YP, Nelson C, Yap YL, Ling MT. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. Int J Cancer 2011; 128: 2182-91.
Ma S^+, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng IO, Man K, Lo CM, Wong N, To KF, Zheng BJ, Lai PB, Chan KW^, Guan XY^. miR-130b promotes CD133+ liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010; 7: 694-707. (^co-corresponding authors) (+Awarded the 2011 Faculty Outstanding Research Output Prize, The University of Hong Kong)
Chen LL, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest 2010; 120: 1178-91.
Ma S, Chan KW, Guan XY. Cancer stem cells - Concepts, methodologies and therapeutic implications. In: Cancer Stem Cells (Ed. XY Guan). Research Signpost 2010, ISBN: 978-81-7895-465-3.
Ma S, Tang KH, Chan KW, Guan XY. Liver cancer stem cells - A review of current literature and protocols. In: Cancer Stem Cells (Ed. XY Guan). Research Signpost 2010, ISBN: 978-81-7895-465-3.
Lee TK, Castilho A, Ma S, Ng IO. Liver cancer stem cells: Implications for a new therapeutic target. Liver Int 2009; 29: 955-65
Chen LL, Hu L, Chan TH, Tsao SW, Xie D, Huo KK, Ma S, Fu L, Zheng BJ, Guan XY. CHD1L suppresses the nucleus-to-mitochondria translocation of Nur77 to sustain hepatocellular carcinoma cell survival. Hepatology 2009; 50: 122-9.
Ma S, Chan YP, Woolcock B, Wong KY, Bainbridge T, Webber D, Guan XY, Lam W, Vielkind J, Chan KW. DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. Int J Cancer 2009; 124: 2323-32.
Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY. CD133+ HCC cancer stem cells promote chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008; 27: 1749-58.
Ma S, Chan KW and Guan XY. In search of liver cancer stem cells. Stem Cell Revs 2008, 4: 179-92.
Ma S+, Chan KW, Lee TK, Tang KH, Wo JY, Zheng BJ, Guan XY. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 2008; 6: 1146-53. (+Most cited 2008 paper from Mol Cancer Res)
Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132: 2542-56.
Ma S, Guan XY, Beh PS, Wong KY, Chan YP, Yuen HF, Vielkind J, Chan KW. Significance of LMO2 expression in progression of prostate cancer. J Pathol 2007; 211: 278-85.
Ma S, Hu L, Huang XH, Cao LQ, Chan KW, Wang Q, Guan XY. Establishment and characterization of a human cholangiocarcinoma cell line. Oncol Rep 2007; 18: 1195-200.
Ma S, Guan XY, Lee TK, Chan KW. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol 2007; 38: 1201-6.
Lee TK, Poon RT, Wo JY, Ma S, Guan XY, Myers JN, Yuen AP. Lupeol suppresses cisplatin induced NFkB activation in HNSCC cells and inhibits local invasion and nodal metastasis in orthotopic nude mouse model of tongue squamous cell carcinoma. Cancer Res 2007; 67; 8800-9.
Lee TK, Poon RT, Man K, Guan XY, Ma S, Liu XB, Myers JN, Yuen AP. Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma. Cancer Lett 2007; 253: 308-15.
Shen J, Ma S, Chan P, Lee W, Fung PC, Cheung RT, Tong Y, Liu KJ. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J Neurochem 2006; 96: 1078-89.
更多详情请访问：http://www.patho.hku.hk/staff/list/stephaniema.htm
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