中山大学生命科学学院副院长郑利民教授
中山大学生命科学学院副院长郑利民教授
Limin Zheng (郑利民) Ph.D., M.D.
Director for Tumor Biotherapy, Cancer Center;
Vice Dean at School of Life Sciences; Sun Yat-sen (Zhong-Shan) Univ.; Guangzhou; China.
Topic:
Inflammation as Novel Strategy for Tumor Immune Editing
About Dr. Limin Zheng
Dr. Limin Zheng graduated from Shanghai Medical University in 1984 and then worked as a physician in Hua-Shan Hospital. He obtained his PhD in Immunology in 1994 from Leiden University, The Netherlands, and was promoted as Assistant Prof. by Swedish Research Council in 1998. Since 2003, he is full Professor at Sun Yat-Sen University, China. He received the Outstanding Young Scientist Fund from NSFC in 2004 and was awarded as “Cheung Kong Scholar” in 2009 by Ministry of Education, China. The main research activity of his Lab is to study the dynamic interactions between the malignant and immune cells in human solid tumors (with a focus on macrophages), as well as the “immune-based molecular staging” and immune therapy for tumors.
Selected Recent Publications:
1. Y Wu, DM Kuang, W Pan, Y Wan, X Li, D Wang, X Lao, and L Zheng. Monocyte/macrophage elicited NK cell dysfunction in Hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology 2012, in press.
2. J Xu, T Ding, Q He, X Yu, W Wu, W Jia, J Yun, Y Zhang, M Shi, C Shao, WD Pan, X Yin, J Min, SM Zhuang and L Zheng. In Situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma. J. Hepatol. 2012. 57: 313-21.
3. Q Zhao, DM Kuang, Y Wu, X Xiao, X Li, T Li, and L Zheng. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J. Immunol. 2012, 188;1117-24.
4. DM Kuang, Q Zhao, Y Wu, C Peng, J Wang, Z Xu, X Yin, and L Zheng. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J. Hepatol. 2011, 54:948-955. Editorial Comment in J Hepatol. 2011, 54:853-5
5. T Ding, J Xu, Y Zhang, RP Guo, W Wei, SD Zhang, CN Qian, and L Zheng. Endothelium coated tumor clusters are associated with poor prognosis and micrometastasis of Hepatocellular carcinoma after resection. Cancer, 2011, 117:4878-89
6. DM Kuang, C Peng, Q Zhao, Y Wu, L Zhu, J Wang, X Yin, L Li, and L Zheng. Tumor activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J. Immunol. 2010. 185:1544-9.
7. DM Kuang, C Peng, Q Zhao, Y Wu, M Chen, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Hepatology. 2010. 51:154-64.
8. JP Zhang, J Yan, J Xu, X Pang, MS Chen, L Li, C Wu, SP Li, and L Zheng. Increased intratumoral IL-17 producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009. 50:980-9.
9. DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, C Wu, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 2009. 206: 1327-37.
10. DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang, and L Zheng. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood, 2007. 110:587-95.
More details: http://www.sysucc.org.cn/kswz_syyjb.asp?selectclassid=009004020031008
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