癌症研究历史经典回顾和热点寻踪（二）
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著名的肿瘤免疫学奠基人之一Richmond T. Prehn首先发现肿瘤特异性抗原，在1970年左右提出肿瘤免疫刺激学说，与诺贝尔奖获得者Bernet的免疫监视学说相反。
1: Prehn RT, Lappe MA. An immunostimulation theory of tumor development.Transplant Rev. 1971;7:26-54. Review.
PMID: 4947774 [PubMed - indexed for MEDLINE]
2: Prehn RT. Immunosurveillance, regeneration and oncogenesis.Prog Exp Tumor Res. 1971;14:1-24. Review. .
PMID: 4944395 [PubMed - indexed for MEDLINE]
3: Prehn RT, Prehn LM. The autoimmune nature of cancer.Cancer Res. 1987 Feb 15;47(4):927-32. Review.
PMID: 3542202 [PubMed - indexed for MEDLINE]
4: Prehn RT, Prehn LM. Immunostimulation of cancer versus immunosurveillance.Medicina (B Aires). 1996;56 Suppl 1:65-73. Review.
PMID: 9224976 [PubMed - indexed for MEDLINE]
5: Prehn RT. Stimulatory effects of immune reactions upon the growths of untransplanted tumors.Cancer Res. 1994 Feb 15;54(4):908-14. Review.
PMID: 8313380 [PubMed - indexed for MEDLINE]
6: Prehn RT. An adaptive immune reaction may be necessary for cancer development.Theor Biol Med Model. 2006 Feb 3;3(1):6 [Epub ahead of print]
PMID: 16457723 [PubMed - as supplied by publisher]
癌症研究的电子理论，即亚分子水平的癌症理论，由诺贝尔奖获得者Szent-Gyorgyi提出，但是癌症研究主流并不支持这种理论，可能只有天才人物才能够挖掘该理论方向的意义。
Electronic Biology and Cancer: a New Theory of Cancer
1: SZENT-GYORGYI A, HEGYELI A, McLAUGHLIN JA. Cancer therapy: a possible new approach.Science. 1963 Jun 28;140:1391-2. No abstract available.
PMID: 13979937 [PubMed - OLDMEDLINE for Pre1966]
2: Szent-Gyorgyi A. Bioelectronics. Intermolecular electron transfer may play a major role in biological regulation, defense, and cancer.Science. 1968 Sep 6;161(845):988-90. .
PMID: 4299558 [PubMed - indexed for MEDLINE]
3: Szent-Gyorgyi A. Bioelectronics and cancer.J Bioenerg. 1973;4:533-62.
PMID: 4771418 [PubMed - indexed for MEDLINE]
4: Szent-Gyorgyi A. The living state and cancer.Proc Natl Acad Sci U S A. 1977 Jul;74(7):2844-7.
PMID: 268635 [PubMed - indexed for MEDLINE]
http://www.ionizers.org/Otto-Warburg.html
著名化学家1931年诺贝尔奖获得者Otto Warburg的癌症理论：无氧代谢理论。
1: WARBURG O. On the origin of cancer cells.Science. 1956 Feb 24;123(3191):309-14. .
PMID: 13298683 [PubMed - OLDMEDLINE for Pre1966]
2: WARBURG O. On respiratory impairment in cancer cells.Science. 1956 Aug 10;124(3215):269-70.
PMID: 13351639 [PubMed - OLDMEDLINE for Pre1966]
3: Arch Geschwulstforsch. 1983;53(1):1-8. Warburg's cancer theory revisited: a fundamentally new approach.Anghileri LJ.
Warburg's cancer theory was based on cell injury at the bioenergetic system level. Posteriorly done research work on cell membrane biology, and on the role of calcium in the multifunctional capabilities of the cell (respiration, protein metabolism, membrane physiology, mitosis, etc.) has been used to corroborate another years ago stated hypothesis on carcinogenesis. The consequently new theory states that a cell injury at the cell membrane level is the event triggering a massive influx of calcium ions, and as the result of which some cells die by toxic death (necrosis) while, in order to survive others must adapt themselves to a changed intracellular ionic environment. This adaptation process leads to a more primitive way of life (neoplasia) where the cells appear to be independent of biological signals, specially those calcium-dependent. The increased intracellular calcium concentration seems also to be the cause of increased cell glycolysis (Warburg's observation), and of the preneoplastic hyperplasia by uncontrolled translational mRNA activity.
4: Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, Pfeiffer AF, Ristow M. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.J Biol Chem. 2006 Jan 13;281(2):977-81. Epub 2005 Nov 1.
PMID: 16263703 [PubMed - indexed for MEDLINE]
第一个发现费城染色体的Nowell PC.及其癌症细胞克隆进化理论。
1: Nowell PC. The clonal evolution of tumor cell populations.Science. 1976 Oct 1;194(4260):23-8.
PMID: 959840 [PubMed - indexed for MEDLINE]
2: Nowell PC. Mechanisms of tumor progression.Cancer Res. 1986 May;46(5):2203-7. Review.
PMID: 3516380 [PubMed - indexed for MEDLINE]
1: Prehn RT, Lappe MA. An immunostimulation theory of tumor development.Transplant Rev. 1971;7:26-54. Review.
PMID: 4947774 [PubMed - indexed for MEDLINE]
2: Prehn RT. Immunosurveillance, regeneration and oncogenesis.Prog Exp Tumor Res. 1971;14:1-24. Review. .
PMID: 4944395 [PubMed - indexed for MEDLINE]
3: Prehn RT, Prehn LM. The autoimmune nature of cancer.Cancer Res. 1987 Feb 15;47(4):927-32. Review.
PMID: 3542202 [PubMed - indexed for MEDLINE]
4: Prehn RT, Prehn LM. Immunostimulation of cancer versus immunosurveillance.Medicina (B Aires). 1996;56 Suppl 1:65-73. Review.
PMID: 9224976 [PubMed - indexed for MEDLINE]
5: Prehn RT. Stimulatory effects of immune reactions upon the growths of untransplanted tumors.Cancer Res. 1994 Feb 15;54(4):908-14. Review.
PMID: 8313380 [PubMed - indexed for MEDLINE]
6: Prehn RT. An adaptive immune reaction may be necessary for cancer development.Theor Biol Med Model. 2006 Feb 3;3(1):6 [Epub ahead of print]
PMID: 16457723 [PubMed - as supplied by publisher]
癌症研究的电子理论，即亚分子水平的癌症理论，由诺贝尔奖获得者Szent-Gyorgyi提出，但是癌症研究主流并不支持这种理论，可能只有天才人物才能够挖掘该理论方向的意义。
Electronic Biology and Cancer: a New Theory of Cancer
1: SZENT-GYORGYI A, HEGYELI A, McLAUGHLIN JA. Cancer therapy: a possible new approach.Science. 1963 Jun 28;140:1391-2. No abstract available.
PMID: 13979937 [PubMed - OLDMEDLINE for Pre1966]
2: Szent-Gyorgyi A. Bioelectronics. Intermolecular electron transfer may play a major role in biological regulation, defense, and cancer.Science. 1968 Sep 6;161(845):988-90. .
PMID: 4299558 [PubMed - indexed for MEDLINE]
3: Szent-Gyorgyi A. Bioelectronics and cancer.J Bioenerg. 1973;4:533-62.
PMID: 4771418 [PubMed - indexed for MEDLINE]
4: Szent-Gyorgyi A. The living state and cancer.Proc Natl Acad Sci U S A. 1977 Jul;74(7):2844-7.
PMID: 268635 [PubMed - indexed for MEDLINE]
http://www.ionizers.org/Otto-Warburg.html
著名化学家1931年诺贝尔奖获得者Otto Warburg的癌症理论：无氧代谢理论。
1: WARBURG O. On the origin of cancer cells.Science. 1956 Feb 24;123(3191):309-14. .
PMID: 13298683 [PubMed - OLDMEDLINE for Pre1966]
2: WARBURG O. On respiratory impairment in cancer cells.Science. 1956 Aug 10;124(3215):269-70.
PMID: 13351639 [PubMed - OLDMEDLINE for Pre1966]
3: Arch Geschwulstforsch. 1983;53(1):1-8. Warburg's cancer theory revisited: a fundamentally new approach.Anghileri LJ.
Warburg's cancer theory was based on cell injury at the bioenergetic system level. Posteriorly done research work on cell membrane biology, and on the role of calcium in the multifunctional capabilities of the cell (respiration, protein metabolism, membrane physiology, mitosis, etc.) has been used to corroborate another years ago stated hypothesis on carcinogenesis. The consequently new theory states that a cell injury at the cell membrane level is the event triggering a massive influx of calcium ions, and as the result of which some cells die by toxic death (necrosis) while, in order to survive others must adapt themselves to a changed intracellular ionic environment. This adaptation process leads to a more primitive way of life (neoplasia) where the cells appear to be independent of biological signals, specially those calcium-dependent. The increased intracellular calcium concentration seems also to be the cause of increased cell glycolysis (Warburg's observation), and of the preneoplastic hyperplasia by uncontrolled translational mRNA activity.
4: Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, Pfeiffer AF, Ristow M. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.J Biol Chem. 2006 Jan 13;281(2):977-81. Epub 2005 Nov 1.
PMID: 16263703 [PubMed - indexed for MEDLINE]
第一个发现费城染色体的Nowell PC.及其癌症细胞克隆进化理论。
1: Nowell PC. The clonal evolution of tumor cell populations.Science. 1976 Oct 1;194(4260):23-8.
PMID: 959840 [PubMed - indexed for MEDLINE]
2: Nowell PC. Mechanisms of tumor progression.Cancer Res. 1986 May;46(5):2203-7. Review.
PMID: 3516380 [PubMed - indexed for MEDLINE]
作者: cypress1975
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