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Cartoon representation of select mouse (Mm), Arabidopsis (At), and Zebrafish (Dr)

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发布日期:2012-09-20 20:55 文章来源:丁香园
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Cartoon representation of select mouse (Mm), Arabidopsis (At), and Zebrafish (Dr)proteins involved in maintenance methylation, de novo methylation, and demethylation.

The MmDnmt3 family and AtDRM2 contain DNA methyltransferase domains (DNA MTase); in AtDRM2 the catalytic motifs are rearranged. The MmDnmt3 proteins also possess a cysteine rich domain that contains a Plant Homeodomain (PHD) zinc finger motif and is referred to as an ATRX-DNMT3-DNMT3L (ADD) domain. MnDnmt3a/b possess a Proline-Tryptophan-Tryptophan-Proline motif (PWWP) that MmDnmt3L lacks. AtDRM2 contains Ubiquitin Associated domains (UBA). MmMIWI2, MmMILI, and AtAGO4 possess a Piwi Argonaute and Zwille domain (PAZ) and a P-element induced wimpy testis domain (PIWI). MmDnmt1 and AtMET1 possess Bromo-Adjacent Homology domains (BAH) and a DNA MTase domain. MmDnmt1 also contains a cysteine rich (CXXC) domain. MmUHRF1 and the AtVIM family contain SET or RING associated (SRA), ring finger E3 ubiquitin protein ligase (RING), and PHD domains. MmUHRF1 also has a Tudor domain and a ubiquitin domain (UBQ). MmLSH1 and AtDDM1 contain DEAD and HELICc helicase domains. AtCMT3 contains a DNA MTase, a Chromatin Organization Modifier (CHROMO) and a BAH domain. AtSUVH4,5, and 6 possess an SRA and a histone methyltransferase domain (Histone MTase). The AtDME/ROS1 family of glycosylases all possesses a helix-hairpin-helix-Gly-Pro-Asp domain (HhH-GDP), a 4Fe-4S cluster (FES), a domain with similarity to histone H1 (H1), and a domain of unknown function (DUF). MmMBD4 contains a HhH-GDP domain and a methyl CpG binding domain (MBD); MmTDG contains a Uracil-DNA glycosylase domain (UDG). Mouse and Zebrafish AID and APOBEC proteins all contain a apolipoprotein B mRNA editing enzyme domain (APOBEC). * indicates activity on additional substrates 145

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